ID   GLCR_BACSU              Reviewed;         258 AA.
AC   P94591; Q795B1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=HTH-type transcriptional repressor GlcR;
GN   Name=glcR; Synonyms=ywpI; OrderedLocusNames=BSU36300;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9353933; DOI=10.1099/00221287-143-10-3313;
RA   Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V.,
RA   Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G.,
RA   Kunst F., Danchin A., Glaser P.;
RT   "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334
RT   degrees).";
RL   Microbiology 143:3313-3328(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION, AND MUTAGENESIS OF THR-35 AND GLY-55.
RX   PubMed=11491085; DOI=10.1007/s002030100288;
RA   Stuelke J., Martin-Verstraete I., Glaser P., Rapoport G.;
RT   "Characterization of glucose-repression-resistant mutants of Bacillus
RT   subtilis: identification of the glcR gene.";
RL   Arch. Microbiol. 175:441-449(2001).
CC   -!- FUNCTION: Plays a role in carbon catabolite repression (CCR).
CC       Specifically required for transcriptional repression of the levanase
CC       operon by glucose but not by other sugars.
CC       {ECO:0000269|PubMed:11491085}.
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DR   EMBL; Z83337; CAB05951.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15647.1; -; Genomic_DNA.
DR   PIR; C69632; C69632.
DR   RefSeq; NP_391511.1; NC_000964.3.
DR   RefSeq; WP_003244075.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P94591; -.
DR   SMR; P94591; -.
DR   IntAct; P94591; 1.
DR   STRING; 224308.BSU36300; -.
DR   PaxDb; P94591; -.
DR   PRIDE; P94591; -.
DR   DNASU; 936908; -.
DR   EnsemblBacteria; CAB15647; CAB15647; BSU_36300.
DR   GeneID; 936908; -.
DR   KEGG; bsu:BSU36300; -.
DR   PATRIC; fig|224308.179.peg.3929; -.
DR   eggNOG; COG1349; Bacteria.
DR   InParanoid; P94591; -.
DR   OMA; YKHSMVA; -.
DR   PhylomeDB; P94591; -.
DR   BioCyc; BSUB:BSU36300-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PRINTS; PR00037; HTHLACR.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..258
FT                   /note="HTH-type transcriptional repressor GlcR"
FT                   /id="PRO_0000360617"
FT   DOMAIN          3..58
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   MUTAGEN         35
FT                   /note="T->I: In grl-30; loss of glucose repression,
FT                   deficiency in glucose transport and absence of ptsG
FT                   expression."
FT                   /evidence="ECO:0000269|PubMed:11491085"
FT   MUTAGEN         55
FT                   /note="G->V: In grl-15; loss of glucose repression,
FT                   deficiency in glucose transport and absence of ptsG
FT                   expression."
FT                   /evidence="ECO:0000269|PubMed:11491085"
SQ   SEQUENCE   258 AA;  28821 MW;  7DD3C5B326E7B796 CRC64;
     MYQEERLVAI LDFLKQHNRI TTEQICTLLQ VSRDTARRDL VKLEEQNAII RTRGGAILPT
     VHQKIQSYSG RLKTVSEEKN KIGRLAASLI HDGDRVILDA STTVQACAKH LNAVDCTVIT
     NSINLADVLS DKEGIEIYLL GGKLEKEHRF LYGSSVIEKL SSYHVDKALI GVVGISEHGI
     TIAHEEDGMV KRKMIQQAKQ VIALADHSKL GSTSFYQYAE LNEIDLLITD RLPNQAFCDL
     LDRNGVELLV TEQDEGKD