GLCTK_DROME
ID GLCTK_DROME Reviewed; 487 AA.
AC Q9VQC4;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Glycerate kinase;
DE EC=2.7.1.31;
GN Name=Glyctk; ORFNames=CG9886;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+);
CC Xref=Rhea:RHEA:23516, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216;
CC EC=2.7.1.31; Evidence={ECO:0000250|UniProtKB:Q8IVS8};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8IVS8}.
CC -!- SIMILARITY: Belongs to the glycerate kinase type-2 family.
CC {ECO:0000305}.
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DR EMBL; AE014134; AAF51252.1; -; Genomic_DNA.
DR EMBL; AY061555; AAL29103.1; -; mRNA.
DR RefSeq; NP_001259941.1; NM_001273012.1.
DR RefSeq; NP_608684.1; NM_134840.3.
DR AlphaFoldDB; Q9VQC4; -.
DR SMR; Q9VQC4; -.
DR STRING; 7227.FBpp0077450; -.
DR PaxDb; Q9VQC4; -.
DR DNASU; 33431; -.
DR EnsemblMetazoa; FBtr0077770; FBpp0077450; FBgn0031428.
DR EnsemblMetazoa; FBtr0335462; FBpp0307439; FBgn0031428.
DR GeneID; 33431; -.
DR KEGG; dme:Dmel_CG9886; -.
DR UCSC; CG9886-RA; d. melanogaster.
DR FlyBase; FBgn0031428; CG9886.
DR VEuPathDB; VectorBase:FBgn0031428; -.
DR eggNOG; KOG3935; Eukaryota.
DR GeneTree; ENSGT00390000014365; -.
DR HOGENOM; CLU_032279_0_0_1; -.
DR InParanoid; Q9VQC4; -.
DR OMA; GKAAWRM; -.
DR OrthoDB; 1371490at2759; -.
DR PhylomeDB; Q9VQC4; -.
DR Reactome; R-DME-70350; Fructose catabolism.
DR BioGRID-ORCS; 33431; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 33431; -.
DR PRO; PR:Q9VQC4; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031428; Expressed in Malpighian tubule and 24 other tissues.
DR ExpressionAtlas; Q9VQC4; baseline and differential.
DR Genevisible; Q9VQC4; DM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008887; F:glycerate kinase activity; ISS:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR Gene3D; 3.40.1480.10; -; 1.
DR Gene3D; 3.40.50.10180; -; 1.
DR InterPro; IPR037035; GK-like_C_sf.
DR InterPro; IPR038614; GK_N_sf.
DR InterPro; IPR007835; MOFRL.
DR InterPro; IPR025286; MOFRL_assoc_dom.
DR InterPro; IPR039760; MOFRL_protein.
DR PANTHER; PTHR12227; PTHR12227; 1.
DR Pfam; PF13660; DUF4147; 1.
DR Pfam; PF05161; MOFRL; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome;
KW Transferase.
FT CHAIN 1..487
FT /note="Glycerate kinase"
FT /id="PRO_0000287197"
SQ SEQUENCE 487 AA; 52792 MW; 3EE52ABCAFF6D6AF CRC64;
MAKRQTWEQM RQIFVQAVNA VHPEKVFADF QKFDLRPQIG ENATDISIKL NGERQDISGK
TCHIVGFGKA VLGMANKVQQ DLGATSAGGV LSVPVNTLKQ FQQPVAPGLV VHEGAANNLP
DENALKAARE IKQLAEKMTA QDILFVFISG GGSALLPLPR SPLTLEDKRS IADKLMKRGA
SIQEINAVRI ACSDIKGGRL ARLAGQAGLL VTFVLSDIIG DPLELIACGP TIQPEAAASP
SDILKKHHVW EELSPEIRRV FEQPEEQKNT SLPEHKVFVV GSNVIATSTA AHEAERLGYI
PCVLSCAVQG DVAQVAGDYQ RLLHGIQEAK QHGILDPQLR EKYAFGERSY PTFRRALEDH
MSSKKPLFLI CGGEPVIKVS GHGLGGRSQH LALLMSQALH RDEAMRDCTF LSAGTDGIDG
PTDAAGAFGD SSVVESYLGD HTLDELAETL RNCDSYNFYK NLAQGEHHVL TGHTGTNVMD
LHFLVVP