ID   GLCTK_RAT               Reviewed;         523 AA.
AC   Q0VGK3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Glycerate kinase;
DE            EC=2.7.1.31;
GN   Name=Glyctk;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+);
CC         Xref=Rhea:RHEA:23516, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216;
CC         EC=2.7.1.31; Evidence={ECO:0000250|UniProtKB:Q8IVS8};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8IVS8}.
CC   -!- SIMILARITY: Belongs to the glycerate kinase type-2 family.
CC       {ECO:0000305}.
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DR   EMBL; BC105621; AAI05622.1; -; mRNA.
DR   RefSeq; NP_001102919.1; NM_001109449.2.
DR   RefSeq; XP_006243918.1; XM_006243856.3.
DR   RefSeq; XP_006243919.1; XM_006243857.3.
DR   AlphaFoldDB; Q0VGK3; -.
DR   SMR; Q0VGK3; -.
DR   STRING; 10116.ENSRNOP00000064339; -.
DR   iPTMnet; Q0VGK3; -.
DR   PhosphoSitePlus; Q0VGK3; -.
DR   PaxDb; Q0VGK3; -.
DR   PRIDE; Q0VGK3; -.
DR   Ensembl; ENSRNOT00000074595; ENSRNOP00000064339; ENSRNOG00000046307.
DR   GeneID; 684314; -.
DR   KEGG; rno:684314; -.
DR   CTD; 132158; -.
DR   RGD; 1591498; Glyctk.
DR   eggNOG; KOG3935; Eukaryota.
DR   GeneTree; ENSGT00390000014365; -.
DR   HOGENOM; CLU_032279_0_0_1; -.
DR   InParanoid; Q0VGK3; -.
DR   OMA; GKAAWRM; -.
DR   OrthoDB; 1371490at2759; -.
DR   PhylomeDB; Q0VGK3; -.
DR   Reactome; R-RNO-70350; Fructose catabolism.
DR   SABIO-RK; Q0VGK3; -.
DR   PRO; PR:Q0VGK3; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000046307; Expressed in liver and 18 other tissues.
DR   Genevisible; Q0VGK3; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008887; F:glycerate kinase activity; IDA:MGI.
DR   GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR   Gene3D; 3.40.1480.10; -; 1.
DR   Gene3D; 3.40.50.10180; -; 1.
DR   InterPro; IPR037035; GK-like_C_sf.
DR   InterPro; IPR038614; GK_N_sf.
DR   InterPro; IPR007835; MOFRL.
DR   InterPro; IPR025286; MOFRL_assoc_dom.
DR   InterPro; IPR039760; MOFRL_protein.
DR   PANTHER; PTHR12227; PTHR12227; 1.
DR   Pfam; PF13660; DUF4147; 1.
DR   Pfam; PF05161; MOFRL; 1.
PE   1: Evidence at protein level;
KW   Acetylation; ATP-binding; Cytoplasm; Kinase; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Transferase.
FT   CHAIN           1..523
FT                   /note="Glycerate kinase"
FT                   /id="PRO_0000287195"
FT   MOD_RES         60
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         200
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8QZY2"
SQ   SEQUENCE   523 AA;  55187 MW;  E6E4E2F009A98243 CRC64;
     MAAALQVLPC LLRAPSRPFL WGPPVARMTS GMALAEQARQ LFDSAVGAVQ PGPMLQRTLS
     LDPSGKQLKV RDRTFQLQEN LYLVGFGKAV LGMAAAADEL LGQHLVQGVI SVPKGIRAAV
     ELAGKQEMLL KPHSHIQVFE GAEDNLPDRD ALRAAQAIQQ LAERLTADDL LLVLISGGGS
     ALLPAPIPPV TLEEKQTLTK LLAARGATIQ ELNTIRKALS QLKGGGLAQA AYPAQVVSLI
     LSDVIGDPLE VIASGPTVAS THSVQDCLHI LNHYGLRAAL PRSVKTVLSR ADSDPHGPHT
     CGHVLNVIIG SNSLALAEAQ RQAEVLGYHA MVLSTAMQGD VRRVAQFYGL LARVAAACLT
     SSTAERPLEE EAKLHQLAAE LQLPDLQLEE ALEAVAKAKG PVCLLAGGEP TVQLQGSGKG
     GRNQELALRV GAELGKQPLG PVDVLFLSGG TDGQDGPTKV AGAWVMSDLV SQASAENLDF
     ATFLDNNDSY TFFCSFQGGT HLLHTGLTGT NVMDVHLLVF HPQ