GLCT_SACS2
ID GLCT_SACS2 Reviewed; 286 AA.
AC Q97UZ0;
DT 03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Glucose import system permease protein GlcT {ECO:0000305};
GN Name=glcT {ECO:0000303|PubMed:11260467};
GN OrderedLocusNames=SSO2848 {ECO:0000312|EMBL:AAK42958.1};
OS Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS (Sulfolobus solfataricus).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Saccharolobus.
OX NCBI_TaxID=273057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN [2]
RP FUNCTION, AND SUBUNIT.
RX PubMed=10400586; DOI=10.1128/jb.181.14.4285-4291.1999;
RA Albers S.V., Elferink M.G., Charlebois R.L., Sensen C.W., Driessen A.J.,
RA Konings W.N.;
RT "Glucose transport in the extremely thermoacidophilic Sulfolobus
RT solfataricus involves a high-affinity membrane-integrated binding
RT protein.";
RL J. Bacteriol. 181:4285-4291(1999).
RN [3]
RP NOMENCLATURE, AND FUNCTION.
RX PubMed=11260467; DOI=10.1046/j.1365-2958.2001.02336.x;
RA Elferink M.G., Albers S.V., Konings W.N., Driessen A.J.;
RT "Sugar transport in Sulfolobus solfataricus is mediated by two families of
RT binding protein-dependent ABC transporters.";
RL Mol. Microbiol. 39:1494-1503(2001).
CC -!- FUNCTION: Part of the ABC transporter complex GlcSTUV involved in
CC glucose uptake. Responsible for the translocation of the substrate
CC across the membrane. {ECO:0000305|PubMed:10400586,
CC ECO:0000305|PubMed:11260467}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (GlcV),
CC two transmembrane proteins (GlcT and GlcU) and a solute-binding protein
CC (GlcS). {ECO:0000305|PubMed:10400586}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; AE006641; AAK42958.1; -; Genomic_DNA.
DR PIR; G90462; G90462.
DR RefSeq; WP_010923999.1; NC_002754.1.
DR AlphaFoldDB; Q97UZ0; -.
DR SMR; Q97UZ0; -.
DR STRING; 273057.SSO2848; -.
DR TCDB; 3.A.1.1.13; the atp-binding cassette (abc) superfamily.
DR EnsemblBacteria; AAK42958; AAK42958; SSO2848.
DR GeneID; 27429114; -.
DR KEGG; sso:SSO2848; -.
DR PATRIC; fig|273057.12.peg.2934; -.
DR eggNOG; arCOG00157; Archaea.
DR HOGENOM; CLU_016047_0_0_2; -.
DR InParanoid; Q97UZ0; -.
DR OMA; LTMTNGQ; -.
DR PhylomeDB; Q97UZ0; -.
DR Proteomes; UP000001974; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..286
FT /note="Glucose import system permease protein GlcT"
FT /id="PRO_0000447613"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 63..275
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 286 AA; 32286 MW; 2478218F158ECB59 CRC64;
MMKKGTIILV APTAIFSAIL LYLVIWNAVM SFMNWSLLNS KPTFVGLETY SIVIRTFQFT
NSLLHSIELS VILVVIGNIL GIFIAALLYF LNSNKARSTF LSIVIYPLSI SMAVNGLIWL
WLFNIHIGVD WLLVRIGLPQ FPWLSSTSTM FPSLVLVSVW AYTGIAALFY LAGFMNIDKT
IVEAARLDGT SAFKILYKIL IPNSLNSFII ATALLFLFSF RIFDLPYVLS GGTTNIFLQT
SELYMYYLFT VEYFSQATAV ATMITLIATI IIIPYALTVI RRWIRR
