GLCU_BACSU
ID GLCU_BACSU Reviewed; 287 AA.
AC P40420; P94429;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Glucose uptake protein GlcU;
GN Name=glcU; Synonyms=ycxE; OrderedLocusNames=BSU03920;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969502; DOI=10.1099/13500872-142-11-3047;
RA Yamane K., Kumano M., Kurita K.;
RT "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome:
RT determination of the sequence of a 146 kb segment and identification of 113
RT genes.";
RL Microbiology 142:3047-3056(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
RX PubMed=3141376; DOI=10.1128/jb.170.11.5086-5092.1988;
RA Rather P.N., Moran C.P. Jr.;
RT "Compartment-specific transcription in Bacillus subtilis: identification of
RT the promoter for gdh.";
RL J. Bacteriol. 170:5086-5092(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 272-287.
RX PubMed=3082854; DOI=10.1128/jb.166.1.238-243.1986;
RA Lampel K.A., Uratani B., Chaudhry G.R., Ramaley R.F., Rudikoff S.;
RT "Characterization of the developmentally regulated Bacillus subtilis
RT glucose dehydrogenase gene.";
RL J. Bacteriol. 166:238-243(1986).
RN [5]
RP FUNCTION.
RX PubMed=10438764; DOI=10.1128/jb.181.16.4929-4936.1999;
RA Fiegler H., Bassias J., Jankovic I., Brueckner R.;
RT "Identification of a gene in Staphylococcus xylosus encoding a novel
RT glucose uptake protein.";
RL J. Bacteriol. 181:4929-4936(1999).
CC -!- FUNCTION: Involved in the uptake of glucose.
CC {ECO:0000269|PubMed:10438764}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed during sporulation.
CC -!- SIMILARITY: Belongs to the GRP transporter (TC 2.A.7.5) family.
CC {ECO:0000305}.
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DR EMBL; D50453; BAA09023.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12200.1; -; Genomic_DNA.
DR EMBL; M23547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M12276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; G69766; G69766.
DR RefSeq; NP_388274.1; NC_000964.3.
DR RefSeq; WP_003234455.1; NZ_JNCM01000031.1.
DR AlphaFoldDB; P40420; -.
DR STRING; 224308.BSU03920; -.
DR TCDB; 2.A.7.5.4; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; P40420; -.
DR EnsemblBacteria; CAB12200; CAB12200; BSU_03920.
DR GeneID; 938268; -.
DR KEGG; bsu:BSU03920; -.
DR PATRIC; fig|224308.179.peg.415; -.
DR eggNOG; COG4975; Bacteria.
DR InParanoid; P40420; -.
DR OMA; VNTKMGG; -.
DR PhylomeDB; P40420; -.
DR BioCyc; BSUB:BSU03920-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR010651; Sugar_transport.
DR PANTHER; PTHR16119; PTHR16119; 2.
DR Pfam; PF06800; Sugar_transport; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Sporulation; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..287
FT /note="Glucose uptake protein GlcU"
FT /id="PRO_0000213623"
FT TRANSMEM 4..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..283
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 287 AA; 30892 MW; E0FF3B0B47EBC56A CRC64;
MDLLLALLPA LFWGSIVLFN VKLGGGPYSQ TLGTTIGALI VSIVIYFFVQ PVLSLRIFIV
GIVSGLFWSL GQANQLKSIQ LMGVSKTMPI STGMQLVSTS LFGVIVFREW STPIAITLGV
LALIFIIVGI ILTSLEDKND KKEGEPSNLK KGILILLVST LGYLVYVVVA RLFNVSGWSA
LLPQAIGMVV GGLVLTYRHK PFNKYAIRNI LPGLIWAGGN MFLFISQPRV GVATSFSLSQ
MGIVISTLGG IFILREKKTK RQLIAIAIGI ILIIAAAVFL GIAKTNS
