ID   GLCU_STAAM              Reviewed;         287 AA.
AC   P60943; Q99S15;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Probable glucose uptake protein GlcU;
GN   Name=glcU; OrderedLocusNames=SAV2256;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Involved in the uptake of glucose. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GRP transporter (TC 2.A.7.5) family.
CC       {ECO:0000305}.
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DR   EMBL; BA000017; BAB58418.1; -; Genomic_DNA.
DR   RefSeq; WP_001159898.1; NC_002758.2.
DR   AlphaFoldDB; P60943; -.
DR   PaxDb; P60943; -.
DR   EnsemblBacteria; BAB58418; BAB58418; SAV2256.
DR   KEGG; sav:SAV2256; -.
DR   HOGENOM; CLU_076024_0_0_9; -.
DR   OMA; VNTKMGG; -.
DR   PhylomeDB; P60943; -.
DR   BioCyc; SAUR158878:SAV_RS12310-MON; -.
DR   PHI-base; PHI:6311; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR010651; Sugar_transport.
DR   PANTHER; PTHR16119; PTHR16119; 2.
DR   Pfam; PF06800; Sugar_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..287
FT                   /note="Probable glucose uptake protein GlcU"
FT                   /id="PRO_0000213625"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  30393 MW;  40DF197AE1C6DCE0 CRC64;
     MQFLDFLIAL LPALFWGSVV LINVFVGGGP YNQIRGTTLG ALIVGLGLLI TGFAKFNNPT
     VIIVGLISGA LWAFGQANQL KSISLIGVSN TMPVSTGMQL VGTTLFSVIF LGEWSSMTQI
     IFGLIAMILL VTGVALTSLK AKNERQSDNP EFKKAMGILI VSTVGYVGFV VLGDIFGVGG
     TDALFFQSVG MAIGGFILSM NHKTSLKSTA LNLLPGVIWG IGNLFMFYSQ PKVGVATSFS
     LSQLLVIVST LGGIFILGER KDRRQMTGIW AGIIIIVIAA IILGNLK