ID   GLCU_STAAS              Reviewed;         287 AA.
AC   Q6G765;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Probable glucose uptake protein GlcU;
GN   Name=glcU; OrderedLocusNames=SAS2147;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Involved in the uptake of glucose. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GRP transporter (TC 2.A.7.5) family.
CC       {ECO:0000305}.
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DR   EMBL; BX571857; CAG43958.1; -; Genomic_DNA.
DR   RefSeq; WP_001159898.1; NC_002953.3.
DR   AlphaFoldDB; Q6G765; -.
DR   KEGG; sas:SAS2147; -.
DR   HOGENOM; CLU_076024_0_0_9; -.
DR   OMA; VNTKMGG; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR010651; Sugar_transport.
DR   PANTHER; PTHR16119; PTHR16119; 2.
DR   Pfam; PF06800; Sugar_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..287
FT                   /note="Probable glucose uptake protein GlcU"
FT                   /id="PRO_0000213628"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  30393 MW;  40DF197AE1C6DCE0 CRC64;
     MQFLDFLIAL LPALFWGSVV LINVFVGGGP YNQIRGTTLG ALIVGLGLLI TGFAKFNNPT
     VIIVGLISGA LWAFGQANQL KSISLIGVSN TMPVSTGMQL VGTTLFSVIF LGEWSSMTQI
     IFGLIAMILL VTGVALTSLK AKNERQSDNP EFKKAMGILI VSTVGYVGFV VLGDIFGVGG
     TDALFFQSVG MAIGGFILSM NHKTSLKSTA LNLLPGVIWG IGNLFMFYSQ PKVGVATSFS
     LSQLLVIVST LGGIFILGER KDRRQMTGIW AGIIIIVIAA IILGNLK