ID   GLCU_STAAW              Reviewed;         287 AA.
AC   P60945; Q99S15;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Probable glucose uptake protein GlcU;
GN   Name=glcU; OrderedLocusNames=MW2175;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Involved in the uptake of glucose. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GRP transporter (TC 2.A.7.5) family.
CC       {ECO:0000305}.
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DR   EMBL; BA000033; BAB96040.1; -; Genomic_DNA.
DR   RefSeq; WP_001159898.1; NC_003923.1.
DR   AlphaFoldDB; P60945; -.
DR   EnsemblBacteria; BAB96040; BAB96040; BAB96040.
DR   KEGG; sam:MW2175; -.
DR   HOGENOM; CLU_076024_0_0_9; -.
DR   OMA; VNTKMGG; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR010651; Sugar_transport.
DR   PANTHER; PTHR16119; PTHR16119; 2.
DR   Pfam; PF06800; Sugar_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..287
FT                   /note="Probable glucose uptake protein GlcU"
FT                   /id="PRO_0000213629"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  30393 MW;  40DF197AE1C6DCE0 CRC64;
     MQFLDFLIAL LPALFWGSVV LINVFVGGGP YNQIRGTTLG ALIVGLGLLI TGFAKFNNPT
     VIIVGLISGA LWAFGQANQL KSISLIGVSN TMPVSTGMQL VGTTLFSVIF LGEWSSMTQI
     IFGLIAMILL VTGVALTSLK AKNERQSDNP EFKKAMGILI VSTVGYVGFV VLGDIFGVGG
     TDALFFQSVG MAIGGFILSM NHKTSLKSTA LNLLPGVIWG IGNLFMFYSQ PKVGVATSFS
     LSQLLVIVST LGGIFILGER KDRRQMTGIW AGIIIIVIAA IILGNLK