GLCU_STAEQ
ID GLCU_STAEQ Reviewed; 287 AA.
AC Q5HLZ2;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Probable glucose uptake protein GlcU;
GN Name=glcU; OrderedLocusNames=SERP1838;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Involved in the uptake of glucose. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the GRP transporter (TC 2.A.7.5) family.
CC {ECO:0000305}.
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DR EMBL; CP000029; AAW55176.1; -; Genomic_DNA.
DR RefSeq; WP_001829716.1; NC_002976.3.
DR AlphaFoldDB; Q5HLZ2; -.
DR STRING; 176279.SERP1838; -.
DR EnsemblBacteria; AAW55176; AAW55176; SERP1838.
DR GeneID; 50018068; -.
DR KEGG; ser:SERP1838; -.
DR eggNOG; COG4975; Bacteria.
DR HOGENOM; CLU_076024_0_0_9; -.
DR OMA; QVAHESS; -.
DR OrthoDB; 778970at2; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR010651; Sugar_transport.
DR PANTHER; PTHR16119; PTHR16119; 2.
DR Pfam; PF06800; Sugar_transport; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..287
FT /note="Probable glucose uptake protein GlcU"
FT /id="PRO_0000213631"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..286
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 287 AA; 30297 MW; C5EE07C42A1F9EB4 CRC64;
MQIVDFLIAL LPALFWGSVV IINVFVGGGP YNQIRGTTLG TLFIGFSLLA TGHAAFDNLT
VIIVGLVSGA LWAFGQGNQL KSVHLIGVSK TMPISTGMQL VGTTLFSAIF LGEWSTIVQV
VMGLIAMILL VVGISLTSLK AKSEGKSDNP EFKKAMGILL LSTIGYVGYV VLGDIFGVSG
TDALFFQSIG MAIGGLILSM NHNTSIKSTA LNLIPGVIWG IGNLFMFYSQ PKVGVATSFS
LSQLLVIVST LGGIFILGEK KDRRQMIGIW SGIIVIVIAS IILGNLK
