ID   GLCU_STAES              Reviewed;         287 AA.
AC   Q8CNF2;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Probable glucose uptake protein GlcU;
GN   Name=glcU; OrderedLocusNames=SE_1829;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Involved in the uptake of glucose. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GRP transporter (TC 2.A.7.5) family.
CC       {ECO:0000305}.
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DR   EMBL; AE015929; AAO05470.1; -; Genomic_DNA.
DR   RefSeq; NP_765384.1; NC_004461.1.
DR   RefSeq; WP_001829716.1; NZ_WBME01000007.1.
DR   AlphaFoldDB; Q8CNF2; -.
DR   STRING; 176280.SE_1829; -.
DR   EnsemblBacteria; AAO05470; AAO05470; SE_1829.
DR   GeneID; 50018068; -.
DR   KEGG; sep:SE_1829; -.
DR   PATRIC; fig|176280.10.peg.1785; -.
DR   eggNOG; COG4975; Bacteria.
DR   HOGENOM; CLU_076024_0_0_9; -.
DR   OMA; QVAHESS; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR010651; Sugar_transport.
DR   PANTHER; PTHR16119; PTHR16119; 2.
DR   Pfam; PF06800; Sugar_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..287
FT                   /note="Probable glucose uptake protein GlcU"
FT                   /id="PRO_0000213630"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  30297 MW;  C5EE07C42A1F9EB4 CRC64;
     MQIVDFLIAL LPALFWGSVV IINVFVGGGP YNQIRGTTLG TLFIGFSLLA TGHAAFDNLT
     VIIVGLVSGA LWAFGQGNQL KSVHLIGVSK TMPISTGMQL VGTTLFSAIF LGEWSTIVQV
     VMGLIAMILL VVGISLTSLK AKSEGKSDNP EFKKAMGILL LSTIGYVGYV VLGDIFGVSG
     TDALFFQSIG MAIGGLILSM NHNTSIKSTA LNLIPGVIWG IGNLFMFYSQ PKVGVATSFS
     LSQLLVIVST LGGIFILGEK KDRRQMIGIW SGIIVIVIAS IILGNLK