ID   GLCU_STAXY              Reviewed;         288 AA.
AC   O07881;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Glucose uptake protein GlcU;
GN   Name=glcU;
OS   Staphylococcus xylosus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=DSM 20267 / Isolate C2A;
RX   PubMed=10438764; DOI=10.1128/jb.181.16.4929-4936.1999;
RA   Fiegler H., Bassias J., Jankovic I., Brueckner R.;
RT   "Identification of a gene in Staphylococcus xylosus encoding a novel
RT   glucose uptake protein.";
RL   J. Bacteriol. 181:4929-4936(1999).
CC   -!- FUNCTION: Involved in the uptake of glucose.
CC       {ECO:0000269|PubMed:10438764}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GRP transporter (TC 2.A.7.5) family.
CC       {ECO:0000305}.
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DR   EMBL; Y14043; CAA74370.1; -; Genomic_DNA.
DR   AlphaFoldDB; O07881; -.
DR   SMR; O07881; -.
DR   STRING; 1288.SXYLSMQ121_0689; -.
DR   TCDB; 2.A.7.5.1; the drug/metabolite transporter (dmt) superfamily.
DR   eggNOG; COG4975; Bacteria.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR010651; Sugar_transport.
DR   PANTHER; PTHR16119; PTHR16119; 2.
DR   Pfam; PF06800; Sugar_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..288
FT                   /note="Glucose uptake protein GlcU"
FT                   /id="PRO_0000213632"
FT   TRANSMEM        4..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   288 AA;  30585 MW;  7556B33EBAE061F2 CRC64;
     MDLLIALLPA LFWGSVVLIN VLVGGGPYNQ IRGTTFGALI IGIILLLTGN AKFDDLTIII
     VGLISGAFWA LGQGYQLKSV SLIGVSKTMP ISTGLQLVGT TLFSAIFLGE WSTGVQVTLG
     LVAMVLLVIG IALTSIKGKN EASESSKNFG KAMPILLIST VGYVVYVVVA QIFGVDGMNA
     LFFQSIGMAI GGLILSAKHE TSVKSTLWNL IPGIVWGIGN LFMFYSQPKV GVATSFSFSQ
     LLVIVSTLGG IFLLGEKKDK RQMIGIWAGI VLIVIAPLYS EILKHNYN