ID   GLD1_HYPJE              Reviewed;         331 AA.
AC   Q0GYU5;
DT   19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=D/L-glyceraldehyde reductase;
DE            EC=1.1.1.372;
GN   Name=gld1;
OS   Hypocrea jecorina (Trichoderma reesei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=51453;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND CATALYTIC ACTIVITY.
RX   PubMed=16930134; DOI=10.1111/j.1742-4658.2006.05423.x;
RA   Liepins J., Kuorelahti S., Penttila M., Richard P.;
RT   "Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-
RT   glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina.";
RL   FEBS J. 273:4229-4235(2006).
CC   -!- FUNCTION: Mediates the conversion of L-glyceraldehyde to glycerol in D-
CC       galacturonate catabolic process. Also able to reduce D-glyceraldehyde.
CC       {ECO:0000269|PubMed:16930134}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH;
CC         Xref=Rhea:RHEA:38111, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754,
CC         ChEBI:CHEBI:27975, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.372; Evidence={ECO:0000269|PubMed:16930134};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH;
CC         Xref=Rhea:RHEA:23592, ChEBI:CHEBI:15378, ChEBI:CHEBI:17378,
CC         ChEBI:CHEBI:17754, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC         EC=1.1.1.372; Evidence={ECO:0000269|PubMed:16930134};
CC   -!- PATHWAY: Carbohydrate acid metabolism.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR   EMBL; DQ422037; ABD83952.1; -; mRNA.
DR   AlphaFoldDB; Q0GYU5; -.
DR   SMR; Q0GYU5; -.
DR   PRIDE; Q0GYU5; -.
DR   BioCyc; MetaCyc:MON-15607; -.
DR   BRENDA; 1.1.1.372; 6451.
DR   SABIO-RK; Q0GYU5; -.
DR   GO; GO:0047956; F:glycerol dehydrogenase [NADP+] activity; IEA:RHEA.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd19118; AKR_AKR3B1-3; 1.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR044490; AKR3B.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; NADP; Oxidoreductase.
FT   CHAIN           1..331
FT                   /note="D/L-glyceraldehyde reductase"
FT                   /id="PRO_0000425567"
FT   ACT_SITE        51
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         114
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         213..276
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   331 AA;  36291 MW;  70680731F27A793A CRC64;
     MSSGRTVTLN TGYKIPQIGY GTWQAAPGEV GAGVFEALKV GYRHLDLAKV YGNQKEVGEG
     IKKALAEVPG LKREDIFITS KLWNNSHKPE DVEPALDDTL AELGLDYLDL YLIHWPVAFA
     PGADLFPKSE DGSEVQLNQN VSIVQTWKAM TELPKSKVRS VGVSNFTIEH LDAVIEATGV
     VPAVNQIERH PRLPNQPLID YCAKKGIIIT AYSAFGNNTK GLPLLVSSDE VKAVADNLSK
     KQGKTVTPAQ VILAWSQIGG HTVIPKSVTK ARIAENFQEV ELDDEAIAAL NKLGEKPQRF
     NIPYTYKPRW NINLFNTEEE KAAAHTAVIK L