GLE1_BOVIN
ID GLE1_BOVIN Reviewed; 698 AA.
AC Q3ZBK7;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=mRNA export factor GLE1 {ECO:0000305};
DE AltName: Full=GLE1 RNA export mediator {ECO:0000305};
DE AltName: Full=GLE1-like protein {ECO:0000305};
DE AltName: Full=Nucleoporin GLE1 {ECO:0000305};
GN Name=GLE1; Synonyms=GLE1L;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Pancreas;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC from the nucleus into the cytoplasm. May be involved in the terminal
CC step of the mRNA transport through the nuclear pore complex (NPC) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associated with the NPC, it however may not be a stable
CC component of the NPC complex since it shuttles between the nucleus and
CC the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and
CC NUPL2 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q53GS7}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q53GS7}. Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q53GS7}. Note=Shuttles between the nucleus and
CC the cytoplasm. Shuttling is essential for its mRNA export function.
CC {ECO:0000250|UniProtKB:Q53GS7}.
CC -!- SIMILARITY: Belongs to the GLE1 family. {ECO:0000305}.
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DR EMBL; BC103239; AAI03240.1; -; mRNA.
DR RefSeq; NP_001029890.1; NM_001034718.2.
DR AlphaFoldDB; Q3ZBK7; -.
DR SMR; Q3ZBK7; -.
DR STRING; 9913.ENSBTAP00000020333; -.
DR PaxDb; Q3ZBK7; -.
DR PRIDE; Q3ZBK7; -.
DR Ensembl; ENSBTAT00000020333; ENSBTAP00000020333; ENSBTAG00000030566.
DR GeneID; 540982; -.
DR KEGG; bta:540982; -.
DR CTD; 2733; -.
DR VEuPathDB; HostDB:ENSBTAG00000030566; -.
DR VGNC; VGNC:29397; GLE1.
DR eggNOG; KOG2412; Eukaryota.
DR GeneTree; ENSGT00390000012903; -.
DR HOGENOM; CLU_024662_1_0_1; -.
DR InParanoid; Q3ZBK7; -.
DR OMA; FWKLLPD; -.
DR OrthoDB; 379050at2759; -.
DR TreeFam; TF324158; -.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000030566; Expressed in oocyte and 110 other tissues.
DR ExpressionAtlas; Q3ZBK7; baseline and differential.
DR GO; GO:0005814; C:centriole; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0044614; C:nuclear pore cytoplasmic filaments; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006446; P:regulation of translational initiation; IBA:GO_Central.
DR GO; GO:0006449; P:regulation of translational termination; IBA:GO_Central.
DR Gene3D; 1.25.40.510; -; 1.
DR InterPro; IPR012476; GLE1.
DR InterPro; IPR038506; GLE1-like_sf.
DR PANTHER; PTHR12960; PTHR12960; 1.
DR Pfam; PF07817; GLE1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; mRNA transport; Nuclear pore complex; Nucleus;
KW Phosphoprotein; Protein transport; Reference proteome; Translocation;
KW Transport.
FT CHAIN 1..698
FT /note="mRNA export factor GLE1"
FT /id="PRO_0000204821"
FT REGION 1..29
FT /note="Interaction with NUP155"
FT /evidence="ECO:0000250"
FT REGION 63..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..483
FT /note="Mediates the shuttling between the nucleus and the
FT cytoplasm"
FT /evidence="ECO:0000250"
FT REGION 656..698
FT /note="Interaction with NUPL2"
FT /evidence="ECO:0000250"
FT COILED 185..246
FT /evidence="ECO:0000255"
FT COILED 308..356
FT /evidence="ECO:0000255"
FT COMPBIAS 63..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q53GS7"
FT MOD_RES 88
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q53GS7"
FT MOD_RES 99
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q53GS7"
FT MOD_RES 351
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R322"
SQ SEQUENCE 698 AA; 79954 MW; 491613D115A36013 CRC64;
MPSEGRCWET LQALRSCDKG RLCYDRDWLL RGEDVLQECM SLPKLSSYSG WVVDHVLPHI
QKNAPPSETS ASSVSTSALD QPSSVPRSPL RNPAYSPVSS ATSNGTKDKY ESPHTEPVVL
QSPRGMKVEG CIRMYELVHR MKGAEGLRQW QEEQEKKVRA LSEMASEQLK RFDERKELKH
HKEFQDLREV MEKSSREALG QQEKLKAEHR HRAKILNLKL REAEQQRLKQ EEQERLRKEE
GQARLRGLYA LQEEVLHLSQ QLDASDQHRD LLQVDLSAFR TRGNQLCSLV SGIIRATSEN
GFPTVEDQAA AEGALQEMRD LLSNLHQEIR RACEEKRRRD EEEARIKQQE SQMQQRPEAH
KELPVPNQGP GAKPNEDLQM KVQDSTMQWY QQLQEASSRC VLAFEGLSNS KDSQAKKIKM
DLQKAATIPV SQISTIAGSK LKEIFDKIHS LLSGKPVQSG GRSVSVTLNP QGLDFVQYKL
AEKFVKQGEE EVASHHEAAF PIAVVASGIW ELHPRVGALI LAHLHKKCPY SVPFYPAFKE
GMALEDYQRM LGYQVKDSKV EQQDNFLKRM SGMIRLYAAI IQLRWPYGNR QETHPHGLNH
GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMILLIKE DYFPRIEAIT
SSGQMGSFIR LKQFLEKCLQ HREVPVPKGF LTASFWRS
