GLE1_DANRE
ID GLE1_DANRE Reviewed; 695 AA.
AC Q6DRB1; Q502U5;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=mRNA export factor GLE1 {ECO:0000305};
DE AltName: Full=GLE1 RNA export mediator {ECO:0000305};
DE AltName: Full=GLE1-like protein {ECO:0000305};
DE AltName: Full=Nucleoporin GLE1 {ECO:0000305};
GN Name=gle1; Synonyms=gle1l;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA Hopkins N.;
RT "Identification of 315 genes essential for early zebrafish development.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-437.
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC from the nucleus into the cytoplasm. May be involved in the terminal
CC step of the mRNA transport through the nuclear pore complex (NPC) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: May associate with the NPC. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q53GS7}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q53GS7}. Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q53GS7}.
CC -!- SIMILARITY: Belongs to the GLE1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH95550.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AY648848; AAT68166.1; -; mRNA.
DR EMBL; BC095550; AAH95550.1; ALT_SEQ; mRNA.
DR AlphaFoldDB; Q6DRB1; -.
DR SMR; Q6DRB1; -.
DR STRING; 7955.ENSDARP00000104523; -.
DR PaxDb; Q6DRB1; -.
DR PRIDE; Q6DRB1; -.
DR ZFIN; ZDB-GENE-040831-4; gle1.
DR eggNOG; KOG2412; Eukaryota.
DR InParanoid; Q6DRB1; -.
DR Reactome; R-DRE-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR PRO; PR:Q6DRB1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0044614; C:nuclear pore cytoplasmic filaments; IBA:GO_Central.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IMP:ZFIN.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0048666; P:neuron development; IMP:ZFIN.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IMP:ZFIN.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0060296; P:regulation of cilium beat frequency involved in ciliary motility; IMP:CACAO.
DR GO; GO:0006446; P:regulation of translational initiation; IBA:GO_Central.
DR GO; GO:0006449; P:regulation of translational termination; IBA:GO_Central.
DR GO; GO:0014044; P:Schwann cell development; IMP:CACAO.
DR GO; GO:0014037; P:Schwann cell differentiation; IMP:ZFIN.
DR GO; GO:0014010; P:Schwann cell proliferation; IMP:ZFIN.
DR Gene3D; 1.25.40.510; -; 1.
DR InterPro; IPR012476; GLE1.
DR InterPro; IPR038506; GLE1-like_sf.
DR PANTHER; PTHR12960; PTHR12960; 1.
DR Pfam; PF07817; GLE1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..695
FT /note="mRNA export factor GLE1"
FT /id="PRO_0000204826"
FT REGION 203..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 105..126
FT /evidence="ECO:0000255"
FT COILED 216..255
FT /evidence="ECO:0000255"
FT COILED 326..433
FT /evidence="ECO:0000255"
FT CONFLICT 18
FT /note="P -> L (in Ref. 1; AAT68166)"
FT /evidence="ECO:0000305"
FT CONFLICT 24
FT /note="Y -> H (in Ref. 1; AAT68166)"
FT /evidence="ECO:0000305"
FT CONFLICT 114..117
FT /note="KEEE -> EKEK (in Ref. 1; AAT68166)"
FT /evidence="ECO:0000305"
FT CONFLICT 124
FT /note="V -> A (in Ref. 1; AAT68166)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 695 AA; 79128 MW; 1839A26690144D37 CRC64;
MPSENLRWET LEALKNSPKG KLKYSPDWVE KGEDVLAGCV EVPSLSPLSG QILKRMSPRM
LLKNCSRSSS VRDTSPGLSE EAAVCRSAPI SPRLKRSSCS LPAVSIQTEE EEEKEEEEKA
EVVVEAPAVS PEASVSTPPA VSVLSPRATQ ISGCIRMCEQ KHKAKAKMEL SLRQEQQERL
VATVANHESE QLKRFEEFME LKQRQEHQSI RDTNEKEAQE SLGRQEKLRE EHRHRMKILN
LRLREMEQQR LREVELERQR QVEGRERHRA INAIQEEVLQ LNRLLQPQQS THAEVEHAPY
ITRGNQLCSQ LSEVVPAAAD DQFPSVEDLS VAERALQEMR SLVRSLQEAV SQAAERKKKK
EQEEEEEKRR QEQLKAQQEE QKKSAALSAK EKAKKEGLQT GADDSTLKWY NSLQDLANQC
AQAFDDLNKA KDTQTKKLKM ELQKAATTPV SQIANSSGAP LKEAFEKIDK LLSRRPVTSA
GKTVSTSQHP QGLEFASYRL AEKFVKQGEE EVASNHSAAF PIGAVASGIW ELHPKIGDLI
LAHLHKKCPY AVPHYPPMES GTSVEDYQKI LGYRVDEGKV EGQDSFLKRM SGMIRLYAAI
IQMRWPYSSK QGLHLHGMNH GWRWMAQILN MEPLADITAT ILFDFLEVCG NALMKQYRVQ
FWKLILIINE EYFPRYLCFA SILHFTCIHW LQNIE
