GLE1_DICDI
ID GLE1_DICDI Reviewed; 837 AA.
AC Q55FW7;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=mRNA export factor GLE1 {ECO:0000305};
DE AltName: Full=Nucleoporin GLE1 {ECO:0000305};
GN Name=gle1; ORFNames=DDB_G0267918;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC from the nucleus into the cytoplasm. May be involved in the terminal
CC step of the mRNA transport through the nuclear pore complex (NPC) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: May associate with the NPC. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nuclear pore
CC complex {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GLE1 family. {ECO:0000305}.
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DR EMBL; AAFI02000003; EAL73412.1; -; Genomic_DNA.
DR RefSeq; XP_647416.1; XM_642324.1.
DR AlphaFoldDB; Q55FW7; -.
DR SMR; Q55FW7; -.
DR STRING; 44689.DDB0189646; -.
DR PaxDb; Q55FW7; -.
DR EnsemblProtists; EAL73412; EAL73412; DDB_G0267918.
DR GeneID; 8616223; -.
DR KEGG; ddi:DDB_G0267918; -.
DR dictyBase; DDB_G0267918; -.
DR eggNOG; KOG2412; Eukaryota.
DR HOGENOM; CLU_339622_0_0_1; -.
DR InParanoid; Q55FW7; -.
DR OMA; QPDICAT; -.
DR PRO; PR:Q55FW7; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0044614; C:nuclear pore cytoplasmic filaments; IDA:dictyBase.
DR GO; GO:0000922; C:spindle pole; IDA:dictyBase.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006446; P:regulation of translational initiation; IBA:GO_Central.
DR GO; GO:0006449; P:regulation of translational termination; IBA:GO_Central.
DR Gene3D; 1.25.40.510; -; 1.
DR InterPro; IPR012476; GLE1.
DR InterPro; IPR038506; GLE1-like_sf.
DR PANTHER; PTHR12960; PTHR12960; 1.
DR Pfam; PF07817; GLE1; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..837
FT /note="mRNA export factor GLE1"
FT /id="PRO_0000344993"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 525..571
FT /evidence="ECO:0000255"
FT COMPBIAS 197..211
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 837 AA; 98690 MW; B937D032B7212A97 CRC64;
MNKTSSNNIS NTNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNRILS PFKRNNSKEN
GNGSVTITLE PLVSPFKLIK SNFKDDVHTN NINNNNNKIK RFLDEDNEFE ITIPIRRSGN
SINFNIGIVP SSNKKQQQQQ QQQQKQKQKK KKTLSPLKKA PGIYSLKDLT IDSDSDSDSY
SDNDDNEEYN IKLKSPIKNK IVNNNNNQQQ QQKQKEKEEK EEKEKVEKDK KEKDKKKLIL
NSFQSELIIN RVEREREIKI NRIVEEKNKE IDDKWVEIKE YNQNQMIKER KEFHSQQIRL
NNLIKKQHKK DIKEFSIKLK QAKQKHQSEL SESLSLLNQL NKLEQQEIDR HNEELLKYEL
AIKEEKRKQQ QLIERYEQKK REEKQRQLQQ EQKEKQEKLE KEEKEKEQQE QQKQLLIKLA
KEKEEKEKFE KEQQQQKEKE LQKEKELLQQ KEKEKEKEKL QQQQQQQQQQ QQQQQQQLQQ
QQQQQNQQNN NLGYIKKDGI IFSLNENSKN FNDFKERSKE FDMIIKFINE KKSMLSREMV
EFERQNSKLI NIAINQISAS QEQVNEKTNK LIKSIQDSQQ SDYLKKSTIL SIVKKSLSQV
ESQITFHNAS SFPLALVLVR VGEKYPELID CLLASLNEKC CYTVPYYVSP KENESQSSIS
KRMGYAFSND IVGDNDKPIE TEDEFHKRIC GYLSLYCALI LKSEQPHKSS SSSSSSSSST
MMFGFGTQIG NNNNNKLINK NLNIESSLRW LKDLVSLRPR RITSYLFVTF FTHLGNLLSK
NQKSSLEFKI IVGKIVEENF FNQMNKPGTE GSFSRLKNLI EEYYKTGTFQ QHEGVDF
