ID   GLE1_PONAB              Reviewed;         698 AA.
AC   Q5RAS2;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=mRNA export factor GLE1 {ECO:0000305};
DE   AltName: Full=GLE1 RNA export mediator {ECO:0000305};
DE   AltName: Full=GLE1-like protein {ECO:0000305};
DE   AltName: Full=Nucleoporin GLE1 {ECO:0000305};
GN   Name=GLE1; Synonyms=GLE1L;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC       from the nucleus into the cytoplasm. May be involved in the terminal
CC       step of the mRNA transport through the nuclear pore complex (NPC) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the NPC, it however may not be a stable
CC       component of the NPC complex since it shuttles between the nucleus and
CC       the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and
CC       NUPL2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q53GS7}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q53GS7}. Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:Q53GS7}. Note=Shuttles between the nucleus and
CC       the cytoplasm. Shuttling is essential for its mRNA export function.
CC       {ECO:0000250|UniProtKB:Q53GS7}.
CC   -!- SIMILARITY: Belongs to the GLE1 family. {ECO:0000305}.
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DR   EMBL; CR858940; CAH91138.1; -; mRNA.
DR   RefSeq; NP_001125666.1; NM_001132194.1.
DR   AlphaFoldDB; Q5RAS2; -.
DR   SMR; Q5RAS2; -.
DR   STRING; 9601.ENSPPYP00000022028; -.
DR   GeneID; 100172586; -.
DR   KEGG; pon:100172586; -.
DR   CTD; 2733; -.
DR   eggNOG; KOG2412; Eukaryota.
DR   InParanoid; Q5RAS2; -.
DR   OrthoDB; 379050at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.510; -; 1.
DR   InterPro; IPR012476; GLE1.
DR   InterPro; IPR038506; GLE1-like_sf.
DR   PANTHER; PTHR12960; PTHR12960; 1.
DR   Pfam; PF07817; GLE1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; mRNA transport; Nuclear pore complex; Nucleus;
KW   Phosphoprotein; Protein transport; Reference proteome; Translocation;
KW   Transport.
FT   CHAIN           1..698
FT                   /note="mRNA export factor GLE1"
FT                   /id="PRO_0000204824"
FT   REGION          1..29
FT                   /note="Interaction with NUP155"
FT                   /evidence="ECO:0000250"
FT   REGION          63..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          335..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..483
FT                   /note="Mediates the shuttling between the nucleus and the
FT                   cytoplasm"
FT                   /evidence="ECO:0000250"
FT   REGION          656..698
FT                   /note="Interaction with NUPL2"
FT                   /evidence="ECO:0000250"
FT   COILED          152..270
FT                   /evidence="ECO:0000255"
FT   COILED          304..356
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        63..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         88
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q53GS7"
FT   MOD_RES         99
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q53GS7"
SQ   SEQUENCE   698 AA;  79911 MW;  F8AE0138B6A174B5 CRC64;
     MPSEGRCWET LQALRSSDKG RLCYYRDWLL RGEDVLEECM CLPKLSSYSG WVVEHVLPHM
     QENQPLSETS PSSTSASALD QPSFVPKSPD TSSAFSPASP ATPNGTKGKD ESQHTESMVL
     QSSRGIKVEG CIRMYELVHR MKGTEGLRQW QEEQERKVRA LSEMASEQLK RFDEWKELKQ
     HKEFQDLREV MEKSSREALG HQEKLKAEHR HRAKILNLKL REAEQQRVKQ AEQERLRKEE
     GQVRLRALYA LREEMLQLSQ QLDASEQHKG LLKVDLAAFQ TRGNQLCSLI SGIIRASSES
     GYPTTESQAE AERALQEMRD LLMNLGQEIT RACEDKRRQD EEEAQVKLQE AQMQQRPEAH
     KEPPAPSQGP GGKQNEDLQV KVQDITMQWY QQLQDASMQC VLTFEGLTNS KDSQAKKIKM
     DLQKAATIPV SQISTIAGSK LKEIFDKIHS LLSGKPVQSG GRSVSVTLNP QGLDFVQYKL
     AEKFVKQGEE EVASHHEAAF PIAVVASGIW ELHPRVGDLI LAHLHKKCPY SVPFYPTFKE
     GMALEDYQRM LGYQVKDSKV EQQDNFLKRM SGMIRLYAAI IQLRWPYGNR QEIHPHGLNH
     GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMLILIKE DYFPRIEAIT
     SSGQMGSFIR LKQFLEKCLQ HKDIPVPKGF LTSSFWRS