GLE1_RAT
ID GLE1_RAT Reviewed; 698 AA.
AC Q4KLN4;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=mRNA export factor GLE1 {ECO:0000305};
DE AltName: Full=GLE1 RNA export mediator {ECO:0000312|RGD:1307329};
DE AltName: Full=GLE1-like protein {ECO:0000305};
DE AltName: Full=Nucleoporin GLE1 {ECO:0000305};
GN Name=Gle1; Synonyms=Gle1l;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Required for the export of mRNAs containing poly(A) tails
CC from the nucleus into the cytoplasm. May be involved in the terminal
CC step of the mRNA transport through the nuclear pore complex (NPC) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associated with the NPC, it however may not be a stable
CC component of the NPC complex since it shuttles between the nucleus and
CC the cytoplasm. Interacts with nuclear pore complex proteins NUP155 and
CC NUPL2 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q53GS7}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q53GS7}. Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:Q53GS7}. Note=Shuttles between the nucleus and
CC the cytoplasm. Shuttling is essential for its mRNA export function.
CC {ECO:0000250|UniProtKB:Q53GS7}.
CC -!- SIMILARITY: Belongs to the GLE1 family. {ECO:0000305}.
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DR EMBL; BC099088; AAH99088.1; -; mRNA.
DR RefSeq; NP_001020902.1; NM_001025731.1.
DR AlphaFoldDB; Q4KLN4; -.
DR SMR; Q4KLN4; -.
DR STRING; 10116.ENSRNOP00000020630; -.
DR iPTMnet; Q4KLN4; -.
DR PhosphoSitePlus; Q4KLN4; -.
DR jPOST; Q4KLN4; -.
DR PaxDb; Q4KLN4; -.
DR Ensembl; ENSRNOT00000099233; ENSRNOP00000092246; ENSRNOG00000015237.
DR GeneID; 362098; -.
DR KEGG; rno:362098; -.
DR UCSC; RGD:1307329; rat.
DR CTD; 2733; -.
DR RGD; 1307329; Gle1.
DR eggNOG; KOG2412; Eukaryota.
DR GeneTree; ENSGT00390000012903; -.
DR HOGENOM; CLU_024662_1_0_1; -.
DR InParanoid; Q4KLN4; -.
DR OMA; FWKLLPD; -.
DR OrthoDB; 379050at2759; -.
DR PhylomeDB; Q4KLN4; -.
DR TreeFam; TF324158; -.
DR Reactome; R-RNO-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR PRO; PR:Q4KLN4; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000015237; Expressed in spleen and 18 other tissues.
DR Genevisible; Q4KLN4; RN.
DR GO; GO:0005814; C:centriole; ISO:RGD.
DR GO; GO:0005813; C:centrosome; ISO:RGD.
DR GO; GO:0036064; C:ciliary basal body; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; ISO:RGD.
DR GO; GO:0044614; C:nuclear pore cytoplasmic filaments; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006446; P:regulation of translational initiation; IBA:GO_Central.
DR GO; GO:0006449; P:regulation of translational termination; IBA:GO_Central.
DR Gene3D; 1.25.40.510; -; 1.
DR InterPro; IPR012476; GLE1.
DR InterPro; IPR038506; GLE1-like_sf.
DR PANTHER; PTHR12960; PTHR12960; 1.
DR Pfam; PF07817; GLE1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; mRNA transport; Nuclear pore complex; Nucleus;
KW Phosphoprotein; Protein transport; Reference proteome; Translocation;
KW Transport.
FT CHAIN 1..698
FT /note="mRNA export factor GLE1"
FT /id="PRO_0000204825"
FT REGION 1..29
FT /note="Interaction with NUP155"
FT /evidence="ECO:0000250"
FT REGION 62..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..483
FT /note="Mediates the shuttling between the nucleus and the
FT cytoplasm"
FT /evidence="ECO:0000250"
FT REGION 656..698
FT /note="Interaction with NUPL2"
FT /evidence="ECO:0000250"
FT COILED 152..274
FT /evidence="ECO:0000255"
FT COILED 305..355
FT /evidence="ECO:0000255"
FT COMPBIAS 333..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q53GS7"
FT MOD_RES 90
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q53GS7"
FT MOD_RES 100
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q53GS7"
FT MOD_RES 351
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R322"
SQ SEQUENCE 698 AA; 79492 MW; 71F45043656B8331 CRC64;
MPSDGRCWET LRALRNSSKG RLRYDREWLL RYEDVLEECM SLPKLSSYSG WVVDHILPNT
SHHTQENAPS SDNSPSSGSA SGLYQSTLKS PVRSSPQSPS PSTPSGTQSA HESPFTEPIA
LQSSRAIKVE GCIRMYELAH RMRGTEGLRQ WQEEQERKVQ ALSEMASEQL KRFDELKELK
LHKEFRDLQE VMEKSTREAL GHQEKLKAEH RHRAKILNLK LREAEQQRVK QAEQEQLRKE
EGQIRLRSLY TLQEEVLQLN QQLDASSQHK DLLNVDLAAF QTRGNQLCGL ISGIIRTTLE
SGYPTAENQA EAERVLQEMR DLLSNLEQEI TRASEMKKKD EEEARVKLQE SQVQQGPGAP
TKTSAPSPSL VGTQSEDLQV KVQDSTMQWY QQLQDASAKC VLAFEDLTSS KDSQIKKIKM
DLQKAATIPV SQISTIAGSK LKEVFDKIHS LLSGKPVQSG GRSVCVTLNP QGLDFVQYKL
AEKFVKQGEE EVASHHEAAF PIAVVASGIW MLHPKVGDLI LAHLHKKCPY SVPFYPAFKE
GMPLEDYQRM LGYQVTDSKV EQQDNFLKRM SGMIRLYAAI IQLQWPYGSR QEAHPHGLNH
GWRWLAQILN MEPLSDVTAT LLFDFLEVCG NALMKQYQVQ FWKMILLIKE DYFPRIEAIT
SSGQMGSFIR LKQFLEKCLQ RREIPVPKGF LTPSFWRS
