GLE1_SCHPO
ID GLE1_SCHPO Reviewed; 480 AA.
AC O94652;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=mRNA export factor gle1 {ECO:0000305};
DE AltName: Full=Nuclear pore protein gle1 {ECO:0000305};
DE AltName: Full=Nucleoporin gle1 {ECO:0000305};
DE AltName: Full=RNA export factor gle1 {ECO:0000305};
GN Name=gle1; ORFNames=SPBC31E1.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC NPC components, collectively referred to as nucleoporins (NUPs), can
CC play the role of both NPC structural components and of docking or
CC interaction partners for transiently associated nuclear transport
CC factors. It is specifically involved in a terminal step of poly(A)+
CC mRNA transport through the NPC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC passive diffusion of ions and small molecules and the active, nuclear
CC transport receptor-mediated bidirectional transport of macromolecules
CC such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC subunits across the nuclear envelope (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus,
CC nuclear pore complex {ECO:0000250}. Nucleus membrane
CC {ECO:0000269|PubMed:16823372}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16823372}; Cytoplasmic side
CC {ECO:0000269|PubMed:16823372}. Nucleus membrane
CC {ECO:0000269|PubMed:16823372}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16823372}; Nucleoplasmic side
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the GLE1 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB39139.1; -; Genomic_DNA.
DR PIR; T40202; T40202.
DR RefSeq; NP_595101.1; NM_001021008.2.
DR AlphaFoldDB; O94652; -.
DR SMR; O94652; -.
DR BioGRID; 276923; 5.
DR IntAct; O94652; 1.
DR STRING; 4896.SPBC31E1.05.1; -.
DR MaxQB; O94652; -.
DR PaxDb; O94652; -.
DR PRIDE; O94652; -.
DR EnsemblFungi; SPBC31E1.05.1; SPBC31E1.05.1:pep; SPBC31E1.05.
DR GeneID; 2540395; -.
DR KEGG; spo:SPBC31E1.05; -.
DR PomBase; SPBC31E1.05; gle1.
DR VEuPathDB; FungiDB:SPBC31E1.05; -.
DR eggNOG; KOG2412; Eukaryota.
DR HOGENOM; CLU_029651_0_0_1; -.
DR InParanoid; O94652; -.
DR OMA; HKRKINP; -.
DR PhylomeDB; O94652; -.
DR Reactome; R-SPO-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR PRO; PR:O94652; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034399; C:nuclear periphery; IDA:PomBase.
DR GO; GO:0005643; C:nuclear pore; IDA:PomBase.
DR GO; GO:0044614; C:nuclear pore cytoplasmic filaments; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR GO; GO:0031369; F:translation initiation factor binding; ISO:PomBase.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IMP:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006446; P:regulation of translational initiation; IBA:GO_Central.
DR GO; GO:0006449; P:regulation of translational termination; IBA:GO_Central.
DR Gene3D; 1.25.40.510; -; 1.
DR InterPro; IPR012476; GLE1.
DR InterPro; IPR038506; GLE1-like_sf.
DR PANTHER; PTHR12960; PTHR12960; 1.
DR Pfam; PF07817; GLE1; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Membrane; mRNA transport; Nuclear pore complex;
KW Nucleus; Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..480
FT /note="mRNA export factor gle1"
FT /id="PRO_0000363391"
FT REGION 128..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 91..190
FT /evidence="ECO:0000255"
SQ SEQUENCE 480 AA; 56295 MW; 0F0C72D1DB283F0F CRC64;
MDTKTTPLIH AKLDEKIISS YNDANGLDID DLWDIYNEKT RRMIHIISQR YKPKKQSPFP
VIADENVRIF PPLHKTIDWA KKRNVEEQNL IEQSITESQR IFSEKQRLEQ ERFNRELLEK
KRIEAERQRL KDEEERRKKE LMEKEKKEKE RIRLIEEQKH KENEQRRLKQ EQIDAKRKEE
EAREKRMKET FKDDPEEDSN MAWSIIHKIK TEVVAPISEK KELKNYCFTQ KRKITPRLGQ
ITKSNSQIMK ITQLLQQTFQ EARNTDPLVY KWVLNFFCKS VVKQAEAEVA VNPISAYPLA
KVCLLLQTQN ADLKDLLFAR LQKNCPWVIP FWYDHGTENG KKKMGFKKLS DGHWEQNTTY
NERQCGIFAV YAAILSLDDS LAPESWRTFS RLLNLPSPSQ LMKSDLELGQ TLCSIVSTYL
DIAGQSLLRI YGRQAKKLIV CSFSEAYLGA NGGGSQYGRL RIVGEDWMKG QGGLKFSFEP
