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GLE2_CHATD
ID   GLE2_CHATD              Reviewed;         357 AA.
AC   G0SEA3; G0ZGV3;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=mRNA export factor GLE2 {ECO:0000305};
DE   AltName: Full=Nuclear pore protein GLE2 {ECO:0000305};
DE   AltName: Full=Nucleoporin GLE2 {ECO:0000305};
GN   Name=GLE2; ORFNames=CTHT_0063040;
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=759272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC       NPC components, collectively referred to as nucleoporins (NUPs), can
CC       play the role of both NPC structural components and of docking or
CC       interaction partners for transiently associated nuclear transport
CC       factors. It is specifically important for nuclear mRNA export.
CC       {ECO:0000250|UniProtKB:P40066}.
CC   -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC       the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC       passive diffusion of ions and small molecules and the active, nuclear
CC       transport receptor-mediated bidirectional transport of macromolecules
CC       such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC       subunits across the nuclear envelope. Due to its 8-fold rotational
CC       symmetry, all subunits are present with 8 copies or multiples thereof.
CC       {ECO:0000250|UniProtKB:P40066, ECO:0000305|PubMed:21784248}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC       {ECO:0000250|UniProtKB:P40066}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:P40066}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P40066}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:P40066}. Nucleus membrane
CC       {ECO:0000250|UniProtKB:P40066}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P40066}; Nucleoplasmic side
CC       {ECO:0000250|UniProtKB:P40066}. Note=Symmetric distribution.
CC       {ECO:0000250|UniProtKB:P40066}.
CC   -!- SIMILARITY: Belongs to the WD repeat rae1 family. {ECO:0000305}.
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DR   EMBL; GL988046; EGS18280.1; -; Genomic_DNA.
DR   EMBL; JF276298; AEL00691.1; -; Genomic_DNA.
DR   RefSeq; XP_006696611.1; XM_006696548.1.
DR   AlphaFoldDB; G0SEA3; -.
DR   SMR; G0SEA3; -.
DR   STRING; 759272.G0SEA3; -.
DR   TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR   EnsemblFungi; EGS18280; EGS18280; CTHT_0063040.
DR   GeneID; 18260342; -.
DR   KEGG; cthr:CTHT_0063040; -.
DR   eggNOG; KOG0647; Eukaryota.
DR   HOGENOM; CLU_038526_1_0_1; -.
DR   OrthoDB; 1048963at2759; -.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR037631; Gle2/RAE1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10971:SF11; PTHR10971:SF11; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Repeat; Translocation; Transport; WD repeat.
FT   CHAIN           1..357
FT                   /note="mRNA export factor GLE2"
FT                   /id="PRO_0000433190"
FT   REPEAT          28..71
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          76..115
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          117..158
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          160..197
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          256..295
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   357 AA;  39411 MW;  10B48D9A61EC99EF CRC64;
     MAGLFGTTTS TTTSTLGDLK NDVELGSPPE DSITDLSFNP NPNDPKDFLA VSSWDKKVRV
     YEIAANGQNQ GKVQMEHEGP VFAVDFFKDG TKVISAGADK QAKVLDLASG QAMQVAAHDA
     PIRCVKYFEA GGTPMAVTGS WDKTIKYWDF RSATPAGTVQ CQERVYTMDV KENLLVIGTA
     DRYIDVINLK EPVKFYKTLQ SPLKWQTRVV SCFTDSQGFA IGSIEGRCAI QYVEDKDQSM
     NFSFKCHRDT PQNNVTNVHA VNAISFHPQH GTFSTAGSDG TFHFWDKDAK HRLKGYPNVG
     GSITATKFNR NGTIFAYAIS YDWSKGYQGN TANYPTKVML HPVLGDECKP RPSVKKR
 
 
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