GLGA1_RHIRD
ID GLGA1_RHIRD Reviewed; 480 AA.
AC P0A3F3; P39670;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Glycogen synthase 1;
DE EC=2.4.1.21;
DE AltName: Full=Starch [bacterial glycogen] synthase 1;
GN Name=glgA1; Synonyms=glgA;
OS Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium
OS radiobacter).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC Agrobacterium tumefaciens complex.
OX NCBI_TaxID=358;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=A348;
RX PubMed=7959036; DOI=10.1016/0378-1119(94)90869-9;
RA Uttaro A.D., Ugalde R.A.;
RT "A chromosomal cluster of genes encoding ADP-glucose synthetase, glycogen
RT synthase and phosphoglucomutase in Agrobacterium tumefaciens.";
RL Gene 150:117-122(1994).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000305}.
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DR EMBL; AF033856; AAD03474.1; -; Genomic_DNA.
DR RefSeq; WP_010973546.1; NZ_JZLL01000074.1.
DR PDB; 1RZU; X-ray; 2.30 A; A/B=1-480.
DR PDB; 1RZV; X-ray; 2.30 A; A/B=1-480.
DR PDBsum; 1RZU; -.
DR PDBsum; 1RZV; -.
DR AlphaFoldDB; P0A3F3; -.
DR SMR; P0A3F3; -.
DR STRING; 1082932.ATCR1_20063; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR DNASU; 1135949; -.
DR eggNOG; COG0297; Bacteria.
DR UniPathway; UPA00164; -.
DR EvolutionaryTrace; P0A3F3; -.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..480
FT /note="Glycogen synthase 1"
FT /id="PRO_0000188586"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000250"
FT STRAND 2..6
FT /evidence="ECO:0007829|PDB:1RZU"
FT TURN 11..13
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 18..31
FT /evidence="ECO:0007829|PDB:1RZU"
FT TURN 32..34
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 36..42
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 45..50
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 55..61
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 63..65
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 68..75
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 78..84
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 86..89
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 91..93
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 95..97
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 101..103
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 107..122
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 126..128
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 132..137
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 138..141
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 144..150
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 151..153
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 158..163
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 173..178
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 183..185
FT /evidence="ECO:0007829|PDB:1RZU"
FT TURN 188..191
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 196..198
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 199..206
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 208..213
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 215..220
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 224..227
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 231..235
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 236..240
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 241..243
FT /evidence="ECO:0007829|PDB:1RZU"
FT TURN 250..252
FT /evidence="ECO:0007829|PDB:1RZU"
FT TURN 255..257
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 261..263
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 267..272
FT /evidence="ECO:0007829|PDB:1RZV"
FT HELIX 273..284
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 289..291
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 293..298
FT /evidence="ECO:0007829|PDB:1RZU"
FT TURN 302..305
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 306..310
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 313..318
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 322..327
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 331..343
FT /evidence="ECO:0007829|PDB:1RZU"
FT TURN 344..347
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 348..353
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 356..365
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 367..371
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 381..388
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 391..397
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 398..403
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 409..413
FT /evidence="ECO:0007829|PDB:1RZU"
FT STRAND 419..424
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 427..441
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 444..455
FT /evidence="ECO:0007829|PDB:1RZU"
FT HELIX 461..475
FT /evidence="ECO:0007829|PDB:1RZU"
SQ SEQUENCE 480 AA; 51709 MW; 771CF7F15FE92B83 CRC64;
MNVLSVSSEI YPLIKTGGLA DVVGALPIAL EAHGVRTRTL IPGYPAVKAA VTDPVKCFEF
TDLLGEKADL LEVQHERLDL LILDAPAYYE RSGGPYLGQT GKDYPDNWKR FAALSLAAAR
IGAGVLPGWR PDMVHAHDWQ AAMTPVYMRY AETPEIPSLL TIHNIAFQGQ FGANIFSKLA
LPAHAFGMEG IEYYNDVSFL KGGLQTATAL STVSPSYAEE ILTAEFGMGL EGVIGSRAHV
LHGIVNGIDA DVWNPATDHL IHDNYSAANL KNRALNKKAV AEHFRIDDDG SPLFCVISRL
TWQKGIDLMA EAVDEIVSLG GRLVVLGAGD VALEGALLAA ASRHHGRVGV AIGYNEPLSH
LMQAGCDAII IPSRFEPCGL TQLYALRYGC IPVVARTGGL ADTVIDANHA ALASKAATGV
QFSPVTLDGL KQAIRRTVRY YHDPKLWTQM QKLGMKSDVS WEKSAGLYAA LYSQLISKGH
