GLGA1_SYNJB
ID GLGA1_SYNJB Reviewed; 491 AA.
AC Q2JNM6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Glycogen synthase 1 {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase 1 {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA1 {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=CYB_0646;
OS Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium
OS Yellowstone B-Prime).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC unclassified Synechococcus.
OX NCBI_TaxID=321332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA-2-3B'a(2-13);
RX PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT "Population level functional diversity in a microbial community revealed by
RT comparative genomic and metagenomic analyses.";
RL ISME J. 1:703-713(2007).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000240; ABD01633.1; -; Genomic_DNA.
DR RefSeq; WP_011432291.1; NC_007776.1.
DR AlphaFoldDB; Q2JNM6; -.
DR SMR; Q2JNM6; -.
DR STRING; 321332.CYB_0646; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR KEGG; cyb:CYB_0646; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_3_3; -.
DR OMA; CGWVHGR; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000001938; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..491
FT /note="Glycogen synthase 1"
FT /id="PRO_0000241802"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 491 AA; 56801 MW; 1FD5318D85281584 CRC64;
MYIVQIASEC APVIKAGGLG DVVYGLSREL EVRGHCVELV LPKYDTMRYD QIWGLHDAYR
DLWVPWYGGA IHCSVYCGWV HGRLCFFIEP HSGDNFFNRG CYYGCPDDNM RFAFFSKAAL
EFLLQSNKRP DIIHCHDWQT GLVPVLLFEI YKYHGMGNQR VCYTIHNFKH QGFGGPEILW
ATGLNREPYY FHYDRLRDNF NPFSLNFMKG GIVFSNFVTT VSPNHALEVQ FGDYGYGLGH
TLYLHRHKFR GVLNGIDYDI WNPEIDRFIP VRYTAQTLEN KAKNKKALRD RLLLQDVDKP
IVAYIGRLDE QKGVHLVHHA IYRSLFKNAQ FVLLGSATER GIGAWFAHEK SYLNNNPDVH
IELGFNEELS HLIYAGADII VVPSHYEPCG LTQMIGLKYG TVPVVRGVGG LVDTVFDRDY
DPHKLPEQRN GYVFYHTDPA ALESALDRAI DLWYTAPDQF RQLQIQGMSY DYSWNYPGKE
YLEIYDFIRH R
