GLGA1_SYNY3
ID GLGA1_SYNY3 Reviewed; 477 AA.
AC P74521;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Glycogen synthase 1;
DE EC=2.4.1.21;
DE AltName: Full=Starch [bacterial glycogen] synthase 1;
GN Name=glgA1; Synonyms=glgA; OrderedLocusNames=sll0945;
OS Synechocystis sp. (strain PCC 6803 / Kazusa).
OC Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC unclassified Synechocystis.
OX NCBI_TaxID=1111708;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 6803 / Kazusa;
RX PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence analysis of the genome of the unicellular cyanobacterium
RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT genome and assignment of potential protein-coding regions.";
RL DNA Res. 3:109-136(1996).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000022; BAA18625.1; -; Genomic_DNA.
DR PIR; S76496; S76496.
DR AlphaFoldDB; P74521; -.
DR SMR; P74521; -.
DR STRING; 1148.1653713; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR PaxDb; P74521; -.
DR PRIDE; P74521; -.
DR EnsemblBacteria; BAA18625; BAA18625; BAA18625.
DR KEGG; syn:sll0945; -.
DR eggNOG; COG0297; Bacteria.
DR InParanoid; P74521; -.
DR OMA; TWCPWYM; -.
DR PhylomeDB; P74521; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000001425; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..477
FT /note="Glycogen synthase 1"
FT /id="PRO_0000188655"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000250"
SQ SEQUENCE 477 AA; 54346 MW; 40C1B6013938E032 CRC64;
MKILFVAAEV SPLAKVGGMG DVVGSLPKVL HQLGHDVRVF MPYYGFIGDK IDVPKEPVWK
GEAMFQQFAV YQSYLPDTKI PLYLFGHPAF DSRRIYGGDD EAWRFTFFSN GAAEFAWNHW
KPEIIHCHDW HTGMIPVWMH QSPDIATVFT IHNLAYQGPW RGLLETMTWC PWYMQGDNVM
AAAIQFANRV TTVSPTYAQQ IQTPAYGEKL EGLLSYLSGN LVGILNGIDT EIYNPAEDRF
ISNVFDADSL DKRVKNKIAI QEETGLEINR NAMVVGIVAR LVEQKGIDLV IQILDRFMSY
TDSQLIILGT GDRHYETQLW QMASRFPGRM AVQLLHNDAL SRRVYAGADV FLMPSRFEPC
GLSQLMAMRY GCIPIVRRTG GLVDTVSFYD PINEAGTGYC FDRYEPLDCF TAMVRAWEGF
RFKADWQKLQ QRAMRADFSW YRSAGEYIKV YKGVVGKPEE LSPMEEEKIA ELTASYR
