ID   GLGA2_METCA             Reviewed;         487 AA.
AC   Q604D9;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Glycogen synthase 2 {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase 2 {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA2 {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=MCA2606;
OS   Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Methylococcales;
OC   Methylococcaceae; Methylococcus.
OX   NCBI_TaxID=243233;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33009 / NCIMB 11132 / Bath;
RX   PubMed=15383840; DOI=10.1371/journal.pbio.0020303;
RA   Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S.,
RA   Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E.,
RA   Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E., Ravel J.,
RA   Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R., Salzberg S.L.,
RA   Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J., Grindhaug S.H.,
RA   Holt I.E., Eidhammer I., Jonasen I., Vanaken S., Utterback T.R.,
RA   Feldblyum T.V., Fraser C.M., Lillehaug J.R., Eisen J.A.;
RT   "Genomic insights into methanotrophy: the complete genome sequence of
RT   Methylococcus capsulatus (Bath).";
RL   PLoS Biol. 2:1616-1628(2004).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAU91308.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE017282; AAU91308.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q604D9; -.
DR   SMR; Q604D9; -.
DR   STRING; 243233.MCA2606; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   EnsemblBacteria; AAU91308; AAU91308; MCA2606.
DR   KEGG; mca:MCA2606; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_3_6; -.
DR   OMA; WDMYHYL; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000006821; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; ISS:JCVI.
DR   GO; GO:0005978; P:glycogen biosynthetic process; ISS:JCVI.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..487
FT                   /note="Glycogen synthase 2"
FT                   /id="PRO_0000230246"
FT   BINDING         12
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   487 AA;  56176 MW;  5E4DB5E897114933 CRC64;
     MHVTPELAPV AKVGGLADVV FGLGRELEIR GNHVEIILPK YDCMRYDQIW GLQRTFDDLW
     VPWYGGAIHC SVYFGFVHGR KCFFIEPHSQ DNFFNRGAVY GFHDDIFRFA FFSRAAMEFL
     WKAGKNPDII HCHDWQTALV PVYLYEIYQP MGMRHPRVCF TIHNFKHQGV TGAQVLHASG
     LDRPEYYFHY DRLRDNHNPH AINLMKGGIV YANFVTTVSP RYAMEAKDQG QGFGLEPTLH
     IHHMKYGGVV NGIDYDVWNP EIDPHIPVHF NVDTIEGKYA DKKALRDRLL LADNEKPIVS
     FVGRLDPQKG IELIRHALFY TLGQGGQFVL LGSSPDGAIN GYFWGLKRQF NDNPDCHLEI
     GYNEELAHLV YAGSDVMVVP SRFEPCGLTQ LIAMRYGTIP VVREIGGLAD TVIDKDFSHR
     PLHERNGYVF RDYDERGLES ALGRAIACYY QYPDHFRELM KNAMRYDYSW NHPGQDYLNI
     YHYIRDK