GLGA2_SYNJA
ID GLGA2_SYNJA Reviewed; 484 AA.
AC Q2JRJ4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Glycogen synthase 2 {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase 2 {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA2 {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=CYA_2648;
OS Synechococcus sp. (strain JA-3-3Ab) (Cyanobacteria bacterium Yellowstone
OS A-Prime).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC unclassified Synechococcus.
OX NCBI_TaxID=321327;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JA-3-3Ab;
RX PubMed=18059494; DOI=10.1038/ismej.2007.46;
RA Bhaya D., Grossman A.R., Steunou A.-S., Khuri N., Cohan F.M., Hamamura N.,
RA Melendrez M.C., Bateson M.M., Ward D.M., Heidelberg J.F.;
RT "Population level functional diversity in a microbial community revealed by
RT comparative genomic and metagenomic analyses.";
RL ISME J. 1:703-713(2007).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000239; ABD00760.1; -; Genomic_DNA.
DR RefSeq; WP_011431431.1; NC_007775.1.
DR AlphaFoldDB; Q2JRJ4; -.
DR SMR; Q2JRJ4; -.
DR STRING; 321327.CYA_2648; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ABD00760; ABD00760; CYA_2648.
DR KEGG; cya:CYA_2648; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_3; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000008818; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..484
FT /note="Glycogen synthase 2"
FT /id="PRO_0000241805"
FT BINDING 17
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 484 AA; 55068 MW; 5F913357CEE1F023 CRC64;
MQARILFAAA EAAPIAKVGG MADVVGSLPV VLRKLGQDVR IIMPLYGFLW DKFGPEPGQY
PRSKDPIWSK QVMGQVADIY ESVLPGTDVP LYLVSHYCFA PHRIYYGEDE FWRFTFFANA
VAEFAWTYYP WKPNIIHCHD WHTGMIPAWM HQAPDIGTVF TIHNLAYQGP WRWQLERMTW
LPWYFSAHNT MAAGILYADQ VNTVSPTYAM EIRTSLHGEG LQDLLAWKGE RLRGILNGID
TEKFDPRTDP ALEANFSIDD LSGRAVNKAA LQSRLGLTVN PDVFLMGMVA RLVEQKGIDL
LIQTLDRFLA YSDSQFVLLG SGEAYYEGRI REMAERHPGR MAYQQGYQPQ LAQLIYGGAD
VFLMPSRFEP CGISQMIAMR YGCVPIARRT GGLVDTVSHH IPSKGIGTGY CFDRYEALDF
YTCLARAWEA FQHKDTWQAL QKRGMATDFS WQRSALEYLR LYELIMNLPL RPEKTSSENQ
PAPT
