GLGA_ACTP7
ID GLGA_ACTP7 Reviewed; 478 AA.
AC B3H0J4;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=APP7_0354;
OS Actinobacillus pleuropneumoniae serotype 7 (strain AP76).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Actinobacillus.
OX NCBI_TaxID=537457;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP76;
RA Linke B., Buettner F., Martinez-Arias R., Goesmann A., Baltes N.,
RA Tegetmeyer H., Singh M., Gerlach G.F.;
RT "Genome and proteome analysis of A. pleuropneumoniae serotype 7.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP001091; ACE61006.1; -; Genomic_DNA.
DR RefSeq; WP_005596321.1; NC_010939.1.
DR AlphaFoldDB; B3H0J4; -.
DR SMR; B3H0J4; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ACE61006; ACE61006; APP7_0354.
DR KEGG; apa:APP7_0354; -.
DR HOGENOM; CLU_009583_18_4_6; -.
DR OMA; TWCPWYM; -.
DR BioCyc; APLE537457:APP7_RS01815-MON; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000001226; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..478
FT /note="Glycogen synthase"
FT /id="PRO_1000126051"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 478 AA; 53563 MW; C8F7520CF46EB329 CRC64;
MKILHICSEM YPLIKTGGLA DVMGALPYAQ QQSGNDVRVL IPLYPQVAEK IGETNEVATI
GTFAGLVTIR FTYFNGLGVY VIDAPHLFQR SGNPYHDSGY ADYPDNYKRF ALLGYLGAQL
SEGLDQWWGK ADILHAHDWQ GGLACAYLKS WNSPVKSVFT IHNIAYPGRF HSYHLHELGL
PWHFFQAEGL EFYGEISYLK AGLYFADKIT TVSPTYALEI TEEIAGGGMH GLLQTRKAQG
RLHGVLNGVD DTVWNPETDT NIVATYKPSY MQGKSKNKAE LQQMFHLPED KDAMLMVMVT
RLTEQKGADF ILDRIDELME ERVQLVVLGS GSPHLEYLLN EARSRHPEQI GIYIGYNEAL
SHQIIAGGDV ILVPSRFEPC GLTQLYGLKY GTLPLVRRTG GLADTVVDSN KESIEQRTAT
GFVFNYPSSD DFLEAFRRAV NLWKKNKLWS SVRQNALAQD FGWARAAASY QAIYQEIV
