GLGA_AQUAE
ID GLGA_AQUAE Reviewed; 463 AA.
AC O66935;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=aq_721;
OS Aquifex aeolicus (strain VF5).
OC Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX NCBI_TaxID=224324;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VF5;
RX PubMed=9537320; DOI=10.1038/32831;
RA Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL Nature 392:353-358(1998).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; AE000657; AAC06894.1; -; Genomic_DNA.
DR PIR; C70363; C70363.
DR RefSeq; NP_213495.1; NC_000918.1.
DR RefSeq; WP_010880433.1; NC_000918.1.
DR AlphaFoldDB; O66935; -.
DR SMR; O66935; -.
DR STRING; 224324.aq_721; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; AAC06894; AAC06894; aq_721.
DR KEGG; aae:aq_721; -.
DR PATRIC; fig|224324.8.peg.578; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_5_0; -.
DR InParanoid; O66935; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000000798; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..463
FT /note="Glycogen synthase"
FT /id="PRO_0000188589"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 463 AA; 53457 MW; D896172D0D3DB27D CRC64;
MRVLFCSSEI YPYAKTGGLA DFSFCLIKYL KKYGVKVKGV MPYYKTLKAE NLRKTDKGVT
LNLNGKDYTF EVYESEDCYF LRNDELFGRD YIYGPPGWGY EDNDIRFGGF SRAVSELIST
GQLEADVVHA NDWQTALIPL FLKEVFKTPV KTVFTIHNLA YQGLFPKETV ERVGIPPYLF
HMEAVEFWGL VNFMKGGIVF SDLITTVSPT YAKEIQTQEY GYGLEGVLKK YSYKLRGILN
GIDYEVWNPE KDKYIYQNYS LRNYSKKFKN KEFLSKELGI EAEKPLISFI NRFTHQKGVE
LILNCAEEMS KLNANFVFLG TGEYENAFLD VSKIYKNFKV FAEFNEGFAR KLYASSDFIL
MPSYFEPCGL TQMIGMRYGC VPIVRKTGGL RDTVKDISEG GYGITFEEPS KETFLCSLKR
AIELYENAKK FRNSVKIVMS LDFSCDRMTK EYIECYEEVQ SHQ
