ID   GLGA_BACSU              Reviewed;         484 AA.
AC   P39125;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Glycogen synthase;
DE            EC=2.4.1.21;
DE   AltName: Full=Starch [bacterial glycogen] synthase;
GN   Name=glgA; OrderedLocusNames=BSU30950;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8145641; DOI=10.1111/j.1365-2958.1994.tb00301.x;
RA   Kiel J.A.K.W., Boels J.M., Beldman G., Venema G.;
RT   "Glycogen in Bacillus subtilis: molecular characterization of an operon
RT   encoding enzymes involved in glycogen biosynthesis and degradation.";
RL   Mol. Microbiol. 11:203-218(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9387221; DOI=10.1099/00221287-143-11-3431;
RA   Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.;
RT   "Sequencing and functional annotation of the Bacillus subtilis genes in the
RT   200 kb rrnB-dnaB region.";
RL   Microbiology 143:3431-3441(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- INDUCTION: Expressed exclusively on media containing carbon sources
CC       that allow efficient sporulation.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000305}.
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DR   EMBL; Z25795; CAA81043.1; -; Genomic_DNA.
DR   EMBL; AF008220; AAC00217.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15073.1; -; Genomic_DNA.
DR   PIR; S40051; S40051.
DR   RefSeq; NP_390973.1; NC_000964.3.
DR   RefSeq; WP_003246015.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; P39125; -.
DR   SMR; P39125; -.
DR   STRING; 224308.BSU30950; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   PaxDb; P39125; -.
DR   PRIDE; P39125; -.
DR   EnsemblBacteria; CAB15073; CAB15073; BSU_30950.
DR   GeneID; 936781; -.
DR   KEGG; bsu:BSU30950; -.
DR   PATRIC; fig|224308.179.peg.3354; -.
DR   eggNOG; COG0297; Bacteria.
DR   InParanoid; P39125; -.
DR   OMA; TWCPWYM; -.
DR   PhylomeDB; P39125; -.
DR   BioCyc; BSUB:BSU30950-MON; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   2: Evidence at transcript level;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..484
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000188597"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   484 AA;  55857 MW;  D479E8064818E0E4 CRC64;
     MKILFAVSEC TPFVKSGGLA DVAGALPKAL ARLGNEVAVM LPKYSQIPEP WKKRMKKQAE
     CTVAVGWRQQ YCGIEHMAEN DVNYYFIDNE YYFNRDSLYG HYDDGERFAF FSRAVLEAAK
     VVNVQADIVH THDWHTAMVN YLLKEEYRKH PFYERMKSVL TIHNLQFQGI FPPDVTHDLL
     GLEMDHFHYE RLECNGFVNF MKAGIIAADH VTTVSPTYRN EIMTPYYGEQ LEQVLQYRED
     DVTGILNGID DTFYQPKSDP YIEAQYDSGD LACKLENKTK LQQRMGLPEK NDIPLISMVT
     RLTKQKGLDL VRRIMHELLE EQDIQLVVLG TGEREFEDYF RYAEFAFHEK CRAYIGFDEP
     LAHQIYAGSD MFLMPSKFEP CGLGQLIALQ YGAIPIVRET GGLYDTVRAY QEEEGTGNGF
     TFSAFNAHDL KFTIERALSF YCQQDVWKSI VKTAMNADYS WGKSAKEYQR IFEQVTRSGR
     DVLE