GLGA_CERS4
ID GLGA_CERS4 Reviewed; 478 AA.
AC Q9RNH6; Q3J2D8;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 3.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=RHOS4_14780;
GN ORFNames=RSP_2885;
OS Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS sphaeroides).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Cereibacter.
OX NCBI_TaxID=272943;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Igarashi R.Y., Meyer C.R.;
RT "Cloning, sequencing, and expression of the ADP-glucose pyrophosphorylase
RT gene (glgC) from Rhodobacter sphaeroides 2.4.1.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC / NCIMB 8253 / ATH 2.4.1.;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD53959.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF181035; AAD53959.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP000143; ABA79046.2; -; Genomic_DNA.
DR RefSeq; WP_023003625.1; NZ_CP030271.1.
DR RefSeq; YP_352947.2; NC_007493.2.
DR AlphaFoldDB; Q9RNH6; -.
DR SMR; Q9RNH6; -.
DR STRING; 272943.RSP_2885; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ABA79046; ABA79046; RSP_2885.
DR GeneID; 57470209; -.
DR KEGG; rsp:RSP_2885; -.
DR PATRIC; fig|272943.9.peg.1821; -.
DR eggNOG; COG0297; Bacteria.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000002703; Chromosome 1.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..478
FT /note="Glycogen synthase"
FT /id="PRO_0000188642"
FT BINDING 20
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
FT CONFLICT 97..99
FT /note="EGG -> GR (in Ref. 1; AAD53959)"
FT /evidence="ECO:0000305"
FT CONFLICT 124..132
FT /note="RIAREGLGD -> GSRARGSGT (in Ref. 1; AAD53959)"
FT /evidence="ECO:0000305"
FT CONFLICT 190
FT /note="E -> K (in Ref. 1; AAD53959)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 478 AA; 50962 MW; 403178D5CBF44F71 CRC64;
METARGRVLS VASECVPLLK TGGLADVVGA LPGALAAEGW EMRVLMPCYR PLKWRLEEME
EVFAEEDLFG GPGRVMAGEV AGRKMLLLDA PHLYDREGGP YAGPDGDWGD NAQRFAALSW
IGARIAREGL GDGWRPDVVH AHDWQAGFTP AYMNYWGSGG ASSVLTVHNI AFQGWAPASL
LSALRLPPQE FHPAALEYYG GLSSLKAGLV SADHITTVSP TYACELMRPE FGMGLQGVIA
QRAGQVTGIL NGVDTDIWSP EVEERPYDAE SLKAKAENRA VLSGAFKLSV PGPLAILVSR
LTYQKGIDLI PEVLPDFIAA GGGLAVLGTG DAPLEAAMRE LEVRFPGRVG VRIGYDEGLS
HLMFAGGDAV LVPSRFEPCG LTQMYGLRYG AIPVVALTGG LADTIINANP AAMAAGCATG
LTFHPTEPPA FAEALRRLIH LYADPAAWET VQRNAMRHPV GWETSAAAYA ALYRELVA
