GLGA_CHLT2
ID GLGA_CHLT2 Reviewed; 474 AA.
AC B0B925;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=CTL0167;
OS Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=471472;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=434/Bu / ATCC VR-902B;
RX PubMed=18032721; DOI=10.1101/gr.7020108;
RA Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT venereum isolates.";
RL Genome Res. 18:161-171(2008).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; AM884176; CAP03612.1; -; Genomic_DNA.
DR RefSeq; WP_009873413.1; NC_010287.1.
DR RefSeq; YP_001654258.1; NC_010287.1.
DR AlphaFoldDB; B0B925; -.
DR SMR; B0B925; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; CAP03612; CAP03612; CTL0167.
DR KEGG; ctb:CTL0167; -.
DR PATRIC; fig|471472.4.peg.180; -.
DR HOGENOM; CLU_009583_18_3_0; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000000795; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..474
FT /note="Glycogen synthase"
FT /id="PRO_1000126059"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 474 AA; 53394 MW; 23F5BA31D3029073 CRC64;
MKIIHTAIEF APVIKAGGLG DALYGLAKAL AANHTTEVVI PLYPKLFTLP KEQDLCSIQK
LSYFFAGEQE ATAFSYFYEG IKVTLFKLDT QPELFENAET IYTSDDAFRF CAFSAAAASY
IQKEGANIVH LHDWHTGLVA GLLKQQPCSQ LQKIVLTLHN FGYRGYTTRE ILEASSLNEF
YISQYQLFRD PQTCVLLKGA LYCSDFVTTV SPTYAKEILE DYSDYEIHDA ITARQHHLRG
ILNGIDTTIW GPETDPNLAK NYTKELFETP SIFFEAKAEN KKALYERLGL SLEHSPCVCI
ISRIAEQKGP HFMKQAILHA LENAYTLIII GTCYGNQLHE EFANLQESLA NSPNVRILLT
YSDVLARQIF AAADMICIPS MFEPCGLTQM IGMRYGTVPL VRATGGLADT VANGINGFSF
FNPHDFYEFR NMLLEAVTTY RTNHDKWQHI VRACLNFSSD LETAANKYLE IYKQ
