ID   GLGA_CLOD6              Reviewed;         480 AA.
AC   Q18A79;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=CD630_08840;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
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DR   EMBL; AM180355; CAJ67717.1; -; Genomic_DNA.
DR   RefSeq; WP_011860977.1; NZ_CP010905.2.
DR   RefSeq; YP_001087358.1; NC_009089.1.
DR   AlphaFoldDB; Q18A79; -.
DR   SMR; Q18A79; -.
DR   STRING; 272563.CD630_08840; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   EnsemblBacteria; CAJ67717; CAJ67717; CD630_08840.
DR   KEGG; cdf:CD630_08840; -.
DR   KEGG; pdc:CDIF630_01004; -.
DR   PATRIC; fig|272563.120.peg.908; -.
DR   eggNOG; COG0297; Bacteria.
DR   OMA; TWCPWYM; -.
DR   PhylomeDB; Q18A79; -.
DR   BioCyc; PDIF272563:G12WB-992-MON; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..480
FT                   /note="Glycogen synthase"
FT                   /id="PRO_1000014347"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   480 AA;  55524 MW;  29980A176CDC0960 CRC64;
     MKVFYVTAEC WPFAKTGGLG DVSYALPKEL KKEGVDVRVI MPKYSTIPSY LKDQLKEIAV
     FSVRVGWRNQ YCGLLEMELD GVKFYFIDNE FYFRREDERK SIYGYGDDAE RYTFFTDAVL
     EAISRIDFYP DVIHINDWHT GMLPLILKER YATLEGYKNI KTMYTIHNLQ YQGVFDKHVL
     YDILDLPQKY FDNGDIEYYG SINFMKAGIN FADKIITVSP TYANEIQTSF YGEQLDGLLR
     KESGKLKGIL NGIDYDLNDP AKDKDIFVHY DVDSINKKVE NKLRLQDILG LKKDSSIPLI
     GIVSRLVSQK GFDLIAYMMP ELMREDLQIV VLGTGEHQYQ SMFNYYDSNF SDKVSARITF
     NASLAQQIYA ASDMFLMPSL FEPCGIGQML AMRYGSLPIV RETGGLRDTV TPYNKFTGEG
     NGFSFKNYNA HEMFFCLKNA IKVFKDKEKW IKLVENAMKT DNSWKKSAKE YIETYRDICD