GLGA_CLOK5
ID GLGA_CLOK5 Reviewed; 475 AA.
AC A5N2Z2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=CKL_3497;
OS Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=431943;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8527 / DSM 555 / NCIMB 10680;
RX PubMed=18218779; DOI=10.1073/pnas.0711093105;
RA Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H.,
RA Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F.,
RA Hagemeier C., Thauer R.K., Gottschalk G.;
RT "The genome of Clostridium kluyveri, a strict anaerobe with unique
RT metabolic features.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000673; EDK35488.1; -; Genomic_DNA.
DR RefSeq; WP_012103819.1; NC_009706.1.
DR AlphaFoldDB; A5N2Z2; -.
DR SMR; A5N2Z2; -.
DR STRING; 431943.CKL_3497; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; EDK35488; EDK35488; CKL_3497.
DR KEGG; ckl:CKL_3497; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_9; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000002411; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..475
FT /note="Glycogen synthase"
FT /id="PRO_1000081321"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 475 AA; 54977 MW; 72BDEEF2C38541BB CRC64;
MKVLFAASES HPFVKTGGLA DVIGTLPRYL KKIGVDVRVV IPKYSAIKSH LASEFNFIKY
FYVPVGWRNK YCGIFQCEYM GVIYYLIDNE YYFFRDELYG YYDDGERFAF FDRAVLDMLW
QINYKPDIIH CNDWHTGMIP VLYKIQYKQS SFYRGVKFVF SIHNLLFQGN FDKNILGELF
NLDGSLYENG SVELNGAVSF MKSGINYSDK ISTVSRSYAF EIQSPEYGEN LDGLLRSRSS
DLWGIVNGID YDIYNPEKDN MIFRNYNKNN LRNKMINKLK IQNDLNLDIN ENVPVLAIIS
RFTPQKGMDI IKTIGERLVS KHVQLIVLGT GYNEYEEYFR YLSSKYPRNV STNIYFDDVL
AHKIYAASDM FLMPSLFEPC GLGQLIALRY GTIPIVRETG GLKDTIIPYN KYTGEGNGFS
FANFDGDDLL RIINDAVDYF EEKDIWNNIV THAMESNNSW DNSAKPYKSL YESLL
