GLGA_CLOPE
ID GLGA_CLOPE Reviewed; 482 AA.
AC Q8XPA1;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=CPE0064;
OS Clostridium perfringens (strain 13 / Type A).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=195102;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13 / Type A;
RX PubMed=11792842; DOI=10.1073/pnas.022493799;
RA Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT eater.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; BA000016; BAB79770.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8XPA1; -.
DR SMR; Q8XPA1; -.
DR STRING; 195102.gene:10489300; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR PRIDE; Q8XPA1; -.
DR EnsemblBacteria; BAB79770; BAB79770; BAB79770.
DR KEGG; cpe:CPE0064; -.
DR HOGENOM; CLU_009583_18_2_9; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000000818; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..482
FT /note="Glycogen synthase"
FT /id="PRO_0000188608"
FT BINDING 21
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 482 AA; 55082 MW; 83640EBF2CE7E9DC CRC64;
MEGFKLIKVL FATSEANPFI KTGGLGDVMG ALPKELKRKG IDARVILPKY SAIKGELLDK
LSFKKWFMVP VGWRNQYCGV YQCEYDEVIY YLLDSEFYFH RNGLYGEGDD GERFAFFDRA
VLETLKEIDW CPDIIHCNDW QTGMIPVLHK LEYSKDPFYK NIKTVTSIHN LLFQGNFSAD
VLPELFGYDY EPVRNGSLEF YGGMSFMKGA INYSDRILTV SETYAKEIKT PYFGENLDGL
LRERGYALKG IVNGIDYDEF NPSKDSLIAK NFSVKTIEDK VLNKLALQKE LGLPINPDIP
MISIVSRLTN QKGCDLIVNI ANRLLQRNVQ LVILGTGDYN YENHFKGLQE LYPTKVSANI
KFDNGLAHRI YASSDIFLMP SLFEPCGLGQ LIALRYGAIP IVRETGGLKD TIHSYNKYTG
IGNGFSFTNY NHNDLMHVIE LALETYDDKE IWRSLIIQAM DSDNSWNKSA EKYKELYEEL
IK
