GLGA_DECAR
ID GLGA_DECAR Reviewed; 485 AA.
AC Q47IJ4;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=Daro_0580;
OS Dechloromonas aromatica (strain RCB).
OC Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales; Azonexaceae;
OC Dechloromonas.
OX NCBI_TaxID=159087;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCB;
RX PubMed=19650930; DOI=10.1186/1471-2164-10-351;
RA Salinero K.K., Keller K., Feil W.S., Feil H., Trong S., Di Bartolo G.,
RA Lapidus A.;
RT "Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB:
RT indications of a surprisingly complex life-style and cryptic anaerobic
RT pathways for aromatic degradation.";
RL BMC Genomics 10:351-351(2009).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000089; AAZ45337.1; -; Genomic_DNA.
DR AlphaFoldDB; Q47IJ4; -.
DR SMR; Q47IJ4; -.
DR STRING; 159087.Daro_0580; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; AAZ45337; AAZ45337; Daro_0580.
DR KEGG; dar:Daro_0580; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_4_4; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..485
FT /note="Glycogen synthase"
FT /id="PRO_0000230239"
FT BINDING 18
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 485 AA; 52712 MW; F129C9391722F697 CRC64;
MSSLSILFAT SEMAPWVKTG GLGDVAAALP AALRKAGHDI RVLLPAYPAL KQAFPTATTV
AELPAFAPGL PASRLLAAQT GKLELLLLDC PELYDRPGNP YLDATGRDWP DNALRFGLLS
RVAARLGQPD SPLSWQPDIV HANDWQTALA PAYLHYQGGA ASVVTVHNIA FQGCFGREML
AALGLPEHAW RFDGVEYHDQ LSFLKAGLQL ASQISTVSPT YAREIQDEHF GYGLAPLLRH
RSAELRGILN GVDTDLWNPA TDPVLATGYA ANRLAAKRTN KAALQTEMGL EVTADRPLFG
VISRLTSQKG LDLLLTVAEG LPELPAQLVV LGSGDKLMEA GFVELAKRFP AQIVVKIGFD
EGLAHRIEAG ADCFVMPSRF EPCGLNQMYS LRYGTPPIVR ATGGLADTVV DVCEDTLADK
SANGFVLDGD TPHALWLTIE HVCRTWQDKK LWQRIQQNGM RRDFSWTHAA NEYVALYRDA
IATRA
