GLGA_DEIRA
ID GLGA_DEIRA Reviewed; 444 AA.
AC Q9RWS1;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2001, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=DR_0594;
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF10170.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE000513; AAF10170.1; ALT_INIT; Genomic_DNA.
DR PIR; B75501; B75501.
DR RefSeq; NP_294317.1; NC_001263.1.
DR RefSeq; WP_027479518.1; NC_001263.1.
DR AlphaFoldDB; Q9RWS1; -.
DR SMR; Q9RWS1; -.
DR STRING; 243230.DR_0594; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR PRIDE; Q9RWS1; -.
DR EnsemblBacteria; AAF10170; AAF10170; DR_0594.
DR KEGG; dra:DR_0594; -.
DR PATRIC; fig|243230.17.peg.772; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_0; -.
DR InParanoid; Q9RWS1; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000002524; Chromosome I.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..444
FT /note="Glycogen synthase"
FT /id="PRO_0000188609"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 444 AA; 48458 MW; 767605781A915302 CRC64;
MRVLHLASEV FPFSRSGGLG DVLGALPAVQ ARLGEDAEVT VLSPWYASLQ GEPQELWRGE
AWGEQAWLGE LRQDGVRYLF LGLNEFQRPG LYHPDDVERF CAFGRAALPA LDAVGVTPDV
LHGHDWQAGL VVAHARLRGL RTAFSVHNLQ YQGRWNLHEA AGWTGLPDWT FGPDGVEFFG
DLNLMKAGLN FAGHVTTVSP TYAQEITTPQ YGEGLEGLLV RLTHEGRLSG ILNGLDQDRW
NPRTDPDIAA YSDPAGKAGA VKALRQEFGL DDAPILATVS RLADQKGMDL LITALPELVR
DWNVVVLGGG DPLLEAALTG WANHPRVAFA SGMNEPLAHR IYAGAHAFAM PSRFEPCGLS
QLIAMRYGTL PIVRETGGLA DTVPPEVGFR FADATAPAFL QACREAQAAF QDPAQWQTRA
TRAMSLDFSW DGPARQYLEL YRGL
