ID   GLGA_GEOSE              Reviewed;         485 AA.
AC   O08328;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Glycogen synthase;
DE            EC=2.4.1.21;
DE   AltName: Full=Starch [bacterial glycogen] synthase;
GN   Name=glgA;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=TRBE14;
RX   PubMed=9244254; DOI=10.1128/jb.179.15.4689-4698.1997;
RA   Takata H., Takaha T., Okada S., Takagi M., Imanaka T.;
RT   "Characterization of a gene cluster for glycogen biosynthesis and a
RT   heterotetrameric ADP-glucose pyrophosphorylase from Bacillus
RT   stearothermophilus.";
RL   J. Bacteriol. 179:4689-4698(1997).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000305}.
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DR   EMBL; D87026; BAA19591.1; -; Genomic_DNA.
DR   AlphaFoldDB; O08328; -.
DR   SMR; O08328; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   UniPathway; UPA00164; -.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT   CHAIN           1..485
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000188596"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   485 AA;  56244 MW;  AEE3338223ECCEAB CRC64;
     MKVLFAVSEC APFAKSGGLA DVAGALPKEL RRLGIDARVM LPKYETIAPE WKKKMKKVAE
     LIVPVGWRRQ YCGVEELRHD GVIYYFIDNE YYFKRPQLYG HYDDGERFAY FCRAVLEVLP
     EIQFQPDVIH CHDWHTGMVP FLLREQYRHE LFYVDMRTVF TIHNLQFQGL FPRGILEDLL
     NLDGRYFTVD HLEFYGCVSF MKGALVASDL ITTVSPTYKE EIQTAYYGER LDGLLRARRD
     DLLGILNGID DEFYNPEADP FLTATYSVHT RERKQLNKRA LQRQFGLPEW DDVPLIAMVT
     RMTAQKGLDL VTCVFHEMMS EDMQLVVLGT GDWRFEQFFS QMAAAYPGKV GVYIGFHEPL
     AHQIYAGADL FLIPSLFEPC GLSQMIALRY GTIPIVRETG GLNDTVQSYN EITKEGNGFS
     FTNFNAHDML YTIRRALSFY RQPSVWEQLT ERAMRGDYSW RRSANQYKQA YEQLIKKEEH
     TLVHG