GLGA_GEOTN
ID GLGA_GEOTN Reviewed; 485 AA.
AC A4IS20;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=GTNG_2779;
OS Geobacillus thermodenitrificans (strain NG80-2).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=420246;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NG80-2;
RX PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA Han W., Peng X., Liu R., Wang L.;
RT "Genome and proteome of long-chain alkane degrading Geobacillus
RT thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000557; ABO68124.1; -; Genomic_DNA.
DR RefSeq; WP_011888027.1; NC_009328.1.
DR AlphaFoldDB; A4IS20; -.
DR SMR; A4IS20; -.
DR STRING; 420246.GTNG_2779; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR PRIDE; A4IS20; -.
DR EnsemblBacteria; ABO68124; ABO68124; GTNG_2779.
DR KEGG; gtn:GTNG_2779; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_9; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000001578; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..485
FT /note="Glycogen synthase"
FT /id="PRO_1000014360"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 485 AA; 56262 MW; 1DFF45594E5A12DA CRC64;
MKVLFAVSEC APFAKSGGLA DVAGALPKEL RRLGIDARVM LPKYETIAPE WKKKMKKVAE
LIVPVGWRRQ YCGVEELRHD GVIYYFIDNE YYFKRPQLYG HYDDGERFAY FCRAVLEVLP
EIQFQPDVIH CHDWHTGMVP FLLREQYRHE LFYVDMRTVF TIHNLQFQGL FPRGILEDLL
NLDGRYFTVD HLEFYGCVSF MKGALVASDL ITTVSPTYKE EIQTAYYGER LDGLLRARRD
DLLGILNGID DEFYNPEADP FLTATYSVHT RERKQLNKRA LQRQFGLPEW DDVPLIAMVT
RMTAQKGLDL VTCVFHEMMS EDMQLVVLGT GDWRFEQFFS QMAAAYPGKV GVYIGFHEPL
AHQIYAGADL FLMPSLFEPC GLSQMIALRY GTIPIVRETG GLNDTVQSYN EITKEGNGFS
FTNFNAHDML YTIRRALSFY RQPSVWEQLT ERAMRGDYSW RRSANQYKQA YEQLIKKEEH
TLVHG
