GLGA_GLAP5
ID GLGA_GLAP5 Reviewed; 477 AA.
AC B8F3S8;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=HAPS_0293;
OS Glaesserella parasuis serovar 5 (strain SH0165) (Haemophilus parasuis).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Glaesserella.
OX NCBI_TaxID=557723;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH0165;
RX PubMed=19074396; DOI=10.1128/jb.01682-08;
RA Yue M., Yang F., Yang J., Bei W., Cai X., Chen L., Dong J., Zhou R.,
RA Jin M., Jin Q., Chen H.;
RT "Complete genome sequence of Haemophilus parasuis SH0165.";
RL J. Bacteriol. 191:1359-1360(2009).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP001321; ACL31980.1; -; Genomic_DNA.
DR RefSeq; WP_010786842.1; NC_011852.1.
DR AlphaFoldDB; B8F3S8; -.
DR SMR; B8F3S8; -.
DR STRING; 557723.HAPS_0293; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ACL31980; ACL31980; HAPS_0293.
DR GeneID; 66618728; -.
DR KEGG; hap:HAPS_0293; -.
DR PATRIC; fig|557723.8.peg.300; -.
DR HOGENOM; CLU_009583_18_4_6; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000006743; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..477
FT /note="Glycogen synthase"
FT /id="PRO_1000135652"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 477 AA; 53478 MW; 4EECA37B736F89B4 CRC64;
MKILHICSEM YPLIKTGGLA DVMGALPYAQ QSAGNDVRVL IPYYPQVASK LGETVEVATV
GTFAGVVTVR FAYLNGLGVY VIDAPHLFDR RLPYYDDNYQ DYTDNYKRFA LLGYLGAQLA
SGLDHWWGRS DVLHAHDWQA GLACAYLKSW NSPVKSVFTI HNIAYPGRFQ AYHLAELALP
WEFFHVNGLE FYGEISYLKA GLFYADRVTA VSPTYAREIT EQIAGAGMHG LLQQRLAEGA
LRGILNGVDD TVWNPETDTN IVANYRPNYM QGKGKNKSEL QRYFGLPEDK DALLFVMVTR
LTEQKGADFL LARIDQIMQH NVQLVVLGSG SPDLEWALRD AQSRYPHKIG LKIGYDEALS
HQIIAGGDVI LVPSRFEPCG LTQLYGLKYG TLPLVRRTGG LADTVNDAHK ESIENRTATG
FVFSYPDADN FYDAVLRAIN LWGKNKLWSS VRQNALAQDF GWAKVAQQYQ ELYYEIV
