GLGA_HAEI8
ID GLGA_HAEI8 Reviewed; 476 AA.
AC Q4QK70;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=NTHI1806;
OS Haemophilus influenzae (strain 86-028NP).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=281310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=86-028NP;
RX PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA Munson R.S. Jr.;
RT "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL J. Bacteriol. 187:4627-4636(2005).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000057; AAX88577.1; -; Genomic_DNA.
DR RefSeq; WP_005656779.1; NC_007146.2.
DR AlphaFoldDB; Q4QK70; -.
DR SMR; Q4QK70; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; AAX88577; AAX88577; NTHI1806.
DR KEGG; hit:NTHI1806; -.
DR HOGENOM; CLU_009583_18_4_6; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000002525; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..476
FT /note="Glycogen synthase"
FT /id="PRO_0000230243"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 476 AA; 52975 MW; 68589161C0974443 CRC64;
MKILHVCSEL YPLLKTGGLA DVLGALPQAQ NQIGLDARVL LPAYPAIIAG IQNTQVVAEF
DNFAGHVVLR YGEYNGVGIY LIDAPHLYGR EGNPYHDAYY NDYGDNYKRF ALLGWVGAEL
ATGLDSWWRA EVVHAHDWHA GLCAAYLFNK GRPAKSVFTI HNLAYQGQFS YHHLYEIGLP
TGMFHVEGLE LFGQISYLKS GLFYSDASTA VSPTYAEEIT TPEFAYGLQG LLSGLKAQGR
LVGILNGVDE NIWHPNVDQY IPHHYKLKYM AGKKKNKAEL QAYFNLPQDE SALAFVMVTR
LTEQKGVDLL IESADEIVKQ GGQLMILGSG APHFEQGIRE LAERYPQNIA VKIGYDEALS
HLMVAGGDVI LVPSRFEPCG LTQLYGLQYG TLPLVRKTGG LADTVVDSTS ESIKARTATG
FVFESATPEA LRHCLQRAFA LWQKPRAWAM VRTDAMEQDF SWRKAAEQYR TLYERL
