ID   GLGA_HAEIN              Reviewed;         476 AA.
AC   P45179;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Glycogen synthase;
DE            EC=2.4.1.21;
DE   AltName: Full=Starch [bacterial glycogen] synthase;
GN   Name=glgA; OrderedLocusNames=HI_1360;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000305}.
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DR   EMBL; L42023; AAC23007.1; -; Genomic_DNA.
DR   PIR; C64119; C64119.
DR   RefSeq; NP_439511.1; NC_000907.1.
DR   RefSeq; WP_010869192.1; NC_000907.1.
DR   AlphaFoldDB; P45179; -.
DR   SMR; P45179; -.
DR   STRING; 71421.HI_1360; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   DNASU; 950277; -.
DR   EnsemblBacteria; AAC23007; AAC23007; HI_1360.
DR   KEGG; hin:HI_1360; -.
DR   PATRIC; fig|71421.8.peg.1413; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_4_6; -.
DR   OMA; TWCPWYM; -.
DR   PhylomeDB; P45179; -.
DR   BioCyc; HINF71421:G1GJ1-1385-MON; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IBA:GO_Central.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..476
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000188620"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   476 AA;  52975 MW;  E4060E820E5D768D CRC64;
     MKILHVCSEL YPLLKTGGLA DVLGALPQAQ NQIGLDARFL LPAYPAITTG IPNTQVVAEF
     DNFAGHVVLR YGEYNGVGIY LIDAPHLYGR EGNPYHDAYY NDYGDNYKRF ALLGWVGAEL
     ATGLDSWWRA EVVHAHDWHA GLCVAYLFNK GKPAKSVFTI HNLAYQGQFS YHHLYEIGLP
     TGMFHVEGLE LFGQISYLKS GLFYSDASTA VSPTYAQEIT TPEFAYGLQG LLSGLKAQGR
     LVGILNGVDE NIWHPNVDQY IPHHYKLKYM AGKKKNKAEL QAYFNLPQDE SALAFVMVTR
     LTEQKGVDLL IESADEIVKQ GGQLMILGSG APHLEQGIRE LAERYPQNIA VKIGYDEALS
     HLMVAGGDVI LVPSRFEPCG LTQLYGLQYG TLPLVRKTGG LADTVVDSTS ESIKARTATG
     FVFESATPEA LRHCLQRAFA LWQKPRAWAM VRTDAMEQDF SWRKAAEQYR TLYERL