GLGA_HAES1
ID GLGA_HAES1 Reviewed; 479 AA.
AC Q0I3I0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=HS_0886;
OS Haemophilus somnus (strain 129Pt) (Histophilus somni).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Histophilus.
OX NCBI_TaxID=205914;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129Pt;
RX PubMed=17172329; DOI=10.1128/jb.01422-06;
RA Challacombe J.F., Duncan A.J., Brettin T.S., Bruce D., Chertkov O.,
RA Detter J.C., Han C.S., Misra M., Richardson P., Tapia R., Thayer N.,
RA Xie G., Inzana T.J.;
RT "Complete genome sequence of Haemophilus somnus (Histophilus somni) strain
RT 129Pt and comparison to Haemophilus ducreyi 35000HP and Haemophilus
RT influenzae Rd.";
RL J. Bacteriol. 189:1890-1898(2007).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000436; ABI25161.1; -; Genomic_DNA.
DR RefSeq; WP_011609039.1; NC_008309.1.
DR AlphaFoldDB; Q0I3I0; -.
DR SMR; Q0I3I0; -.
DR STRING; 205914.HS_0886; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ABI25161; ABI25161; HS_0886.
DR KEGG; hso:HS_0886; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_4_6; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..479
FT /note="Glycogen synthase"
FT /id="PRO_1000014364"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 479 AA; 53446 MW; BE30DB786BB0CB54 CRC64;
MKVLHVCSEL YPLLKTGGLA DVMGALPFAQ NEIGIDARLV LPAYPAISRG IPNTVVVAEF
NNFAGHVVLR YGEYNGIGVY LIDAPHLYAR EGNPYHDMWY NDYTDNYKRF ALLAWVGAEL
ATGLDFWWRA EIVHAHDWHA GLTAAYLHHK GRPAKSVFTI HNLAYQGRFL PYHLTEIGLP
WWMFNVDGLE LYGEMSYLKA GLYYSDISTA VSPTYAKEIT TPEFAYGLQG LLQTLKAQGR
LVGILNGVDE KIWHPYSDPY IEDHYKLKSM QGKRKNKIKL QAYFNLPQNP NALLFVMVTR
LTEQKGVDLL IGSAERIVQQ GGQLAILGSG SAHLEAGINW LAQEYPENIA VKIGYDEALS
HLMIAGGDVI LVPSRFEPCG LTQLYGLKYG TLPLVRSTGG LADTVIDSSS ENIKARHATG
FVFNDADVGG LCYGIDSAFT LWRKPSQWES VIVNAMEQDF SWQTSAKGYQ SLYDILLHK
