GLGA_HYDS0
ID GLGA_HYDS0 Reviewed; 482 AA.
AC B4U626;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484};
GN OrderedLocusNames=HY04AAS1_0004;
OS Hydrogenobaculum sp. (strain Y04AAS1).
OC Bacteria; Aquificae; Aquificales; Aquificaceae; Hydrogenobaculum;
OC unclassified Hydrogenobaculum.
OX NCBI_TaxID=380749;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Y04AAS1;
RX PubMed=19136599; DOI=10.1128/jb.01645-08;
RA Reysenbach A.-L., Hamamura N., Podar M., Griffiths E., Ferreira S.,
RA Hochstein R., Heidelberg J., Johnson J., Mead D., Pohorille A.,
RA Sarmiento M., Schweighofer K., Seshadri R., Voytek M.A.;
RT "Complete and draft genome sequences of six members of the Aquificales.";
RL J. Bacteriol. 191:1992-1993(2009).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP001130; ACG56696.1; -; Genomic_DNA.
DR RefSeq; WP_012513053.1; NC_011126.1.
DR AlphaFoldDB; B4U626; -.
DR SMR; B4U626; -.
DR STRING; 380749.HY04AAS1_0004; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ACG56696; ACG56696; HY04AAS1_0004.
DR KEGG; hya:HY04AAS1_0004; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_5_0; -.
DR OMA; CGWVHGR; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..482
FT /note="Glycogen synthase"
FT /id="PRO_1000126080"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 482 AA; 55194 MW; 495C78730D21656E CRC64;
MKICFVASEC EPLVKVGGLG DVVQSLAKEL VNLGHQVSVI LPFYKSIKAQ NVQFITQHTL
NLGGVYYDFH IYKTNLDNVD IFLIDQKTFF GREYVYGTPK GPYEDNYLRF AFFSLASLET
LSHVCHIPDI IHIHDWHTAL VAVYKDLYFK HLDETATVLT IHNIAFQGIF LGHILPQIGI
PWGLFNPEDL EFYNQVNFLK GGIVHSDVIT TVSKTHAKEI QTNMGFGLEG VLREKRYVFG
ILNGIDTESW NPATDKSLYQ NYDINTFKAG KEKNKMYVKE LFGLETPHTR PLAAFIARLA
KQKGLDLIEK AVDDAVKIGY DFIFLGSGDY YYQGKVLDMV KRNMGYVAAR IEYNDILSRK
LYAGADMFLM PSEYEPCGIG QMIAMRYGAI PIVHKTGGLA DTVVDYNEDN EHGTGFSFED
YTYKDFLYTM ARAMIVYQKK YIPEDNEWYN IVSNAMAQDF SWRRSVQEYI KIYKTAKLIK
MH
