ID   GLGA_LACAC              Reviewed;         476 AA.
AC   Q5FL65;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=LBA0683;
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM;
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
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DR   EMBL; CP000033; AAV42559.1; -; Genomic_DNA.
DR   RefSeq; WP_003546574.1; NC_006814.3.
DR   RefSeq; YP_193590.1; NC_006814.3.
DR   AlphaFoldDB; Q5FL65; -.
DR   SMR; Q5FL65; -.
DR   STRING; 272621.LBA0683; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   PRIDE; Q5FL65; -.
DR   EnsemblBacteria; AAV42559; AAV42559; LBA0683.
DR   GeneID; 56942315; -.
DR   KEGG; lac:LBA0683; -.
DR   PATRIC; fig|272621.13.peg.653; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_2_9; -.
DR   OMA; TWCPWYM; -.
DR   BioCyc; LACI272621:G1G49-705-MON; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..476
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000230244"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   476 AA;  54822 MW;  C77DE5FC9C7FBF9A CRC64;
     MRVLFTGAEC APFFKTGGLG DVLGSLPNQL AKEGVDVGVV LPLYQDLPEK YRKNLKYQGN
     FIVPVGWRNQ YCGIFTLKLN GVNYFFIDNE YYFKRPGIYG YYDDGERYAY FQQAVIMMME
     RFDFIPDVLH CNDYHTAFIP FLLHEKWGFV DAYKGIKTIL TIHNLEFQGK YNAKTLPDFF
     GMNYDWFDSG IVRMDNDVNW MKTGILYADR VTTVSPSYAR EIQTVEFGQG LDAILRMCSH
     KLTGILNGID FEKYNPKTDP VIKKNYDVYH LHHKSKDKIA LQKELDLPIK PNIPLIGMVS
     RLTAQKGCQL LLDELDNILQ FNVQIVILGN GDPYYEHRLM EIAERYPDKL KVILAFDVKL
     AQRIYAGADS FLMPSAFEPC GLSQLIALRY GTLPIVHEIG GLADTVWVYD ETTNEGTGFG
     FKEFSGYQMV QAIKKMLALY QQKNNWLKIQ KIAMKSDFSW KNSADKYKWM YGELIG