ID   GLGA_LACLA              Reviewed;         478 AA.
AC   Q9CHM9;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=LL0699;
GN   ORFNames=L98347;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK04797.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005176; AAK04797.1; ALT_INIT; Genomic_DNA.
DR   PIR; C86712; C86712.
DR   RefSeq; NP_266855.1; NC_002662.1.
DR   RefSeq; WP_014570454.1; NC_002662.1.
DR   AlphaFoldDB; Q9CHM9; -.
DR   SMR; Q9CHM9; -.
DR   STRING; 272623.L98347; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   PaxDb; Q9CHM9; -.
DR   EnsemblBacteria; AAK04797; AAK04797; L98347.
DR   KEGG; lla:L98347; -.
DR   PATRIC; fig|272623.7.peg.750; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_2_9; -.
DR   OMA; TWCPWYM; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..478
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000188621"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   478 AA;  54273 MW;  FEB5A596507278A1 CRC64;
     MKVLFASSEC APFFKTGGLG DVAGALPKEL AKKSEIDSVA VILPYFKNEM KEEYRSLLKD
     EFYDFVDVGW RHEYVGVKSL EKEGVKYYFL DNEHYFGRGQ LYGYGDDGER FAFFDLALCQ
     LLEKLDFIPD VLHVNDWQTA MVPFLLKEKY NWIKAYEKIK TVLTIHNIEF QGLMHGDALS
     ELFGMGMERY FEGVVRHNGM LNMLKTGILY ADRVNTVSPT YAKEIQTSEF GCGLESILQY
     VDGKVSGILN GIDYDIYNPE NDILIPYHFS EEELSGKGQM KAELQKRTGL PLNPNVPLIG
     MVSRLTNQKG FDLVLSQLEK VLEENVQIVL LGTGFPEIEE GFRYFSQKYP DKLSANIAFD
     IQFAQEIYAG SDFFLMPSAF EPCGLSQMIA MRYGTLPIVH EIGGLKDTVI PFNPISKEGT
     GFGFVDFEGQ ILVETINRAL EVYGKEPEVL NKMVLSAMSK DFSWGTKAQQ YIELYQEL