ID   GLGA_LEPBP              Reviewed;         476 AA.
AC   B0SPF1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=LEPBI_I2990;
OS   Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=456481;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Patoc 1 / ATCC 23582 / Paris;
RX   PubMed=18270594; DOI=10.1371/journal.pone.0001607;
RA   Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N.,
RA   Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A.,
RA   Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L.,
RA   Rood J.I., Lajus A., Davies J.K., Medigue C., Adler B.;
RT   "Genome sequence of the saprophyte Leptospira biflexa provides insights
RT   into the evolution of Leptospira and the pathogenesis of leptospirosis.";
RL   PLoS ONE 3:E1607-E1607(2008).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
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DR   EMBL; CP000786; ABZ99057.1; -; Genomic_DNA.
DR   RefSeq; WP_012389915.1; NC_010602.1.
DR   AlphaFoldDB; B0SPF1; -.
DR   SMR; B0SPF1; -.
DR   STRING; 456481.LEPBI_I2990; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   KEGG; lbi:LEPBI_I2990; -.
DR   HOGENOM; CLU_009583_18_2_12; -.
DR   OMA; TWCPWYM; -.
DR   OrthoDB; 83240at2; -.
DR   BioCyc; LBIF456481:LEPBI_RS14645-MON; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000001847; Chromosome I.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..476
FT                   /note="Glycogen synthase"
FT                   /id="PRO_1000126084"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   476 AA;  54553 MW;  BE24E4D3A95BAED4 CRC64;
     MKILHASAEY FPYTKMGGLA DMLASLTKEQ SRTEEVYVAL PLIGKLGKEP NWTGKEVGAL
     LPQDAKEETI AVSLLAKARF REAIESGVKL YFFDSELFSG LNSIYGQADE HYRFAIFSYA
     CYALSQILQV DVFHAHDWHT ALSLTLQKNS TKPIPSLFTI HNLAYQGDHP FWMTGFLKED
     PFYLITSPFD QDGKCNYMKA GILSAGQITT VSPGYREETL REPNGFGLSY VLKKRKADYT
     GILNGIDPDE WNPKVDKRIF QTYHLQNWKE GKRKNKEHLY REIGRPNVSL DLPLIGLIGR
     LTYQKGFPTF LQAFLERRHL PHRYVVLGSG DPETENAFFH LSDMMPDVFY FYKGYNESLA
     HQIEAASDFF LMPSLFEPCG LNQMYSHVYG TIPIVSRVGG LRDTVDESID IQFKTGIVFE
     PNDKSSLGYA LERANDLFVS PERDHVVKNM MNLDWTWTKR KLEYDRVYKI AIELLE