GLGA_LIGS1
ID GLGA_LIGS1 Reviewed; 476 AA.
AC Q1WSN1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=LSL_1291;
OS Ligilactobacillus salivarius (strain UCC118) (Lactobacillus salivarius).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=362948;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCC118;
RX PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K.,
RA Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W.;
RT "Multireplicon genome architecture of Lactobacillus salivarius.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000233; ABE00098.1; -; Genomic_DNA.
DR RefSeq; WP_011476257.1; NC_007929.1.
DR RefSeq; YP_536181.1; NC_007929.1.
DR AlphaFoldDB; Q1WSN1; -.
DR SMR; Q1WSN1; -.
DR STRING; 362948.LSL_1291; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ABE00098; ABE00098; LSL_1291.
DR KEGG; lsl:LSL_1291; -.
DR PATRIC; fig|362948.14.peg.1365; -.
DR HOGENOM; CLU_009583_18_2_9; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000006559; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..476
FT /note="Glycogen synthase"
FT /id="PRO_1000014368"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 476 AA; 54096 MW; 3926E6BDAE8F3185 CRC64;
MKLLFAGSEC APFFKTGGLG DVMGALPKTI AKTTDNDVRV VLPFFTGMAE EYKSQLSFVT
SFYVKVGWRD QYCGVLKLEM DNVTYYFIDN LYYFDRPGLY GYYDEGERWA FFQQAIIEML
EKIGFIPDIL HVNDYHTAFI PFLLKEKYGW INAYQSIKTV LTIHNLQFQG EYGREVLGEL
FNLDASYYDD GTVRFDTAVN FMKTGILYAD KVNTVSPTYA SEIQTEAFGQ GLDEILRMHN
WKLRGILNGI DYERNNPATD KNLVANYSAK KLKGKVKDKL ALQKEFGLPQ RKDVPVIAMV
SRLTAQKGFQ LVVSEMQNLV QFDVQVIVLG TGDANFEHDF RYFADTYPDK VGAAITFDVG
LAQRIYAGAD MFLMPSAFEP CGLSQMISMR YGTLPIVHQI GGLQDSVQPF NPVTGEGTGF
GFHDFSGFYM MQEIQEALRL YAESVAWTKV VKQAMSQDFS WETASQEYLN MYNELV
