ID   GLGA_METJA              Reviewed;         521 AA.
AC   Q59001;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Probable glycogen synthase;
DE            EC=2.4.1.21;
DE   AltName: Full=Starch [bacterial glycogen] synthase;
GN   Name=glgA; OrderedLocusNames=MJ1606;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000305}.
CC   -!- CAUTION: Could lack activity as the potential ADP-glucose binding site
CC       Arg/Lys residue in position 15 is replaced by an Ser. {ECO:0000305}.
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DR   EMBL; L77117; AAB99625.1; -; Genomic_DNA.
DR   PIR; E64500; E64500.
DR   RefSeq; WP_010871131.1; NC_000909.1.
DR   AlphaFoldDB; Q59001; -.
DR   SMR; Q59001; -.
DR   STRING; 243232.MJ_1606; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   EnsemblBacteria; AAB99625; AAB99625; MJ_1606.
DR   GeneID; 1452515; -.
DR   KEGG; mja:MJ_1606; -.
DR   eggNOG; arCOG01420; Archaea.
DR   HOGENOM; CLU_545885_0_0_2; -.
DR   InParanoid; Q59001; -.
DR   OMA; HNEAFKG; -.
DR   OrthoDB; 83551at2157; -.
DR   PhylomeDB; Q59001; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..521
FT                   /note="Probable glycogen synthase"
FT                   /id="PRO_0000188668"
SQ   SEQUENCE   521 AA;  59736 MW;  68B1E0DE40715CC2 CRC64;
     MKIVILAPTI TPIVSYGGLG DVMRDLPKFL KKGNEVVVLT LNHYNRYFTL PYEDIKKITV
     IYKGAKITFD VLRTKHPTTG VDLIVFSNES VNNLNVWDPI KYEIFADLVI TYLDEVKDID
     VVSGHDWMCG LAIAKCNDIL DLPTTLTIHN EAFKGEMIEY KGEVMTFLEL GIKYADAVNT
     VSPSHAEEIK NYPYIKKYLN NKPFCGILNG IDIDEYDPMK IIERMCNLSN NKLDPRNYAY
     ISPYSAEDSH NIKPKIKYSW FYRGGVYEYV EDWNKIDKGI SATDVEVHGG VDGDIETPLI
     GFVGRATHQK GFNTMFEAIP ELLEKHDIRF VFLTKGDRDI EERLKNLANE HDGRILALIG
     YSLPLSSLVF AGSDWIIMPS YWEPCGLVQM EAMAYCTPVI ATETGGLKDT IIPLHPNPYE
     HPNFDKATGV LFKVPDKVGF MWGVEHALNW TFYKLNEICM FMQYIRYKCP KHPYDENSPL
     SMMMKNCYYH VFRNLSWQNS PSIRKYKGLF GGAIYNHYLQ P