GLGA_MOOTA
ID GLGA_MOOTA Reviewed; 487 AA.
AC Q2RH55;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=Moth_1936;
OS Moorella thermoacetica (strain ATCC 39073 / JCM 9320).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Moorella group; Moorella.
OX NCBI_TaxID=264732;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39073 / JCM 9320;
RX PubMed=18631365; DOI=10.1111/j.1462-2920.2008.01679.x;
RA Pierce E., Xie G., Barabote R.D., Saunders E., Han C.S., Detter J.C.,
RA Richardson P., Brettin T.S., Das A., Ljungdahl L.G., Ragsdale S.W.;
RT "The complete genome sequence of Moorella thermoacetica (f. Clostridium
RT thermoaceticum).";
RL Environ. Microbiol. 10:2550-2573(2008).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000232; ABC20234.1; -; Genomic_DNA.
DR RefSeq; WP_011393434.1; NC_007644.1.
DR RefSeq; YP_430777.1; NC_007644.1.
DR AlphaFoldDB; Q2RH55; -.
DR SMR; Q2RH55; -.
DR STRING; 264732.Moth_1936; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ABC20234; ABC20234; Moth_1936.
DR KEGG; mta:Moth_1936; -.
DR PATRIC; fig|264732.11.peg.2099; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_9; -.
DR OMA; CGWVHGR; -.
DR UniPathway; UPA00164; -.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..487
FT /note="Glycogen synthase"
FT /id="PRO_0000230247"
FT BINDING 19
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 487 AA; 55385 MW; DAD7EB5492D84408 CRC64;
MNKPLKILLV SPEVAPLAKT GGLADVAGSL PKALAAKGHE VRVAMPRYRQ VKEVNYLTDL
PVEMDGSLET AVIRQGKLPG EAGIPVYLID NYKFFYRDGM YGYGDDAARF NFFCKAVLSM
LPWLEFQPDI IHCNDWQTGP IPLFLKVKHE DNPFYRETAT IYTIHNLQYQ GTFPRNILKT
MALSEEFFVP ERLEFYGQVS YMKAGILYAD LVNTVSKKYA LEIQTPEYGE RLDGLLRKRA
ADLRGILNGI DYEEFDPATD RRLAVNYDAD HLEKKGENKA ALQREMELPV RDVPVLGLIS
RLVSQKGLDL LAAILDPLMQ QDLQFVLLGS GEDYYQQLFS RYKVKYRDKM AVKIGFDPVL
AQHIYAGCDI FLMPSRFEPC GLGQMISLRY GAVPVVRATG GLEDTIKDLH QYPGVGNGFT
FRDYQPQALL DTINRALHVY RHEPGEWRKL MRRGMAADFS WSASAGHYEE MYREALEKRR
AAMFKVG
