GLGA_NOSP7
ID GLGA_NOSP7 Reviewed; 479 AA.
AC B2J471;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=Npun_F3799;
OS Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=63737;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP001037; ACC82183.1; -; Genomic_DNA.
DR RefSeq; WP_012410154.1; NC_010628.1.
DR AlphaFoldDB; B2J471; -.
DR SMR; B2J471; -.
DR STRING; 63737.Npun_F3799; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ACC82183; ACC82183; Npun_F3799.
DR KEGG; npu:Npun_F3799; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_3; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR PhylomeDB; B2J471; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000001191; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..479
FT /note="Glycogen synthase"
FT /id="PRO_1000126087"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 479 AA; 55062 MW; 1EEC3331C3135A51 CRC64;
MRILFVAAEA APIAKVGGMG DVVGALPKFL REMGHDVRIF LPYYGFLPDK MEIPKEPIWR
GSAMFQEFAV YESVLPGTDV PLYLFGHPVF LPRRIYSGDD EDWRFTFFSN GAAEFAWNYW
KPDIIHCHDW HTGMIPVWMH QDPDITTVFT IHNLAYQGPW RWYLEKITWC PWYMQGHNTM
AAAVQFANKV NTVSPTYAEQ IKTPAYGETL EGLLSFISGK LSGIINGIDT EVYNPEDDKY
IAQTFTTETL DKRKANKIAL QEEVGLEVNS KAFLIGIVTR LVEQKGIDLI LQILDRFLSY
TDAQFVLLGT GDRYYETQMW QLASRFPGRM ATYLLYNDAL SRRIYAGTDA FLMPSRFEPC
GISQMMSLRY GSVPIVRRTG GLVDTVSHHD PENAAGTGYC FDRYEPLDLF TCMIRAWEGF
RFKPQWQELQ KRGMSEDFSW YKSAKEYVKL YRSIYGLPEE EETPKPELVL NEAVTNSKS