GLGA_PARUW
ID GLGA_PARUW Reviewed; 500 AA.
AC Q6MAS9;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=pc1596;
OS Protochlamydia amoebophila (strain UWE25).
OC Bacteria; Chlamydiae; Parachlamydiales; Parachlamydiaceae;
OC Candidatus Protochlamydia.
OX NCBI_TaxID=264201;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UWE25;
RX PubMed=15073324; DOI=10.1126/science.1096330;
RA Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U.,
RA Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., Rattei T.,
RA Mewes H.-W., Wagner M.;
RT "Illuminating the evolutionary history of chlamydiae.";
RL Science 304:728-730(2004).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; BX908798; CAF24320.1; -; Genomic_DNA.
DR RefSeq; WP_011176142.1; NC_005861.1.
DR AlphaFoldDB; Q6MAS9; -.
DR SMR; Q6MAS9; -.
DR STRING; 264201.pc1596; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; CAF24320; CAF24320; PC_RS07650.
DR KEGG; pcu:PC_RS07650; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_3_0; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000000529; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..500
FT /note="Glycogen synthase"
FT /id="PRO_0000188627"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 500 AA; 58201 MW; 52FD3869D894BC30 CRC64;
MHIIHIASEL APLAKVGGLA DVVLGLCREL SWKGHDVDII IPKYDCMDSE QIRDLTVDYF
ELPSFYNGEW FFNTVWMGWV ENLKVYFIEP HHPRFFFNRG CFYGCEDDLE RFLYFSRTAL
EFLYKKSILP DIIHLHDWQT AVIAPLYKDM YQKLGYTKPK ILFTIHNMEY QGKCAAHDLN
YIGLDGNRYQ QHSFMQDNLY PHLINLLKGG IVYSDFVTTV SPNYAKEVLT PKEGRGLEAT
LVEYQHKFKG ILNGIDYSYW NPEIDRFLPA HYSLREMPKN KKDRNTVDKK GFIKKILREK
LYLAEEHRPI IGCITRLVPQ KGIDLIKHTI RHIVEKKGQF ILLGSSPIPS INDEFHRLKH
QYTDHPHIHL ILHHSEELAH LIYAGSDMFI VPSLFEPCGL TQIIALKYGT VPIVRRTGGL
ADTIIDVDHT DQQPDKKNGY VFDDPDANGI DSAIDRAIHC WFEEPEKWRQ LMLNGMKMDF
SWNQSSDCYL KIYQAISAKN
