GLGA_PROA2
ID GLGA_PROA2 Reviewed; 491 AA.
AC B4S584;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=Paes_2020;
OS Prosthecochloris aestuarii (strain DSM 271 / SK 413).
OC Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC Prosthecochloris.
OX NCBI_TaxID=290512;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 271 / SK 413;
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Anderson I., Liu Z., Li T., Zhao F., Overmann J.,
RA Bryant D.A., Richardson P.;
RT "Complete sequence of chromosome of Prosthecochloris aestuarii DSM 271.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP001108; ACF47030.1; -; Genomic_DNA.
DR RefSeq; WP_012506563.1; NC_011059.1.
DR AlphaFoldDB; B4S584; -.
DR SMR; B4S584; -.
DR STRING; 290512.Paes_2020; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ACF47030; ACF47030; Paes_2020.
DR KEGG; paa:Paes_2020; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_0_10; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000002725; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..491
FT /note="Glycogen synthase"
FT /id="PRO_1000126090"
FT BINDING 20
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 491 AA; 55461 MW; 42F064F0FCF55E2B CRC64;
MSRSTCKVLY VSGEISPFIR VSALADFMAS FPHAMEEEGC EARIMMPKYG VINDRKFRLH
DVLRLSDIEV RSKEKTDLLH VKVTALPSSK IQTYFLYNEK YFKRNALFAD MQQGSDVKNS
LERVVFFNLG VLETLQRLGW KPDIIHCQDW YAGLVPLLLK TMYADCEFFK DIRTVLTVHN
AYRQGIYPLK GFKKMLPSEV IDKMHVEDDT VNMLFTAVEH FDAVTTTSDA YAGMLADGRS
EAFGLDRVIE KRASGLVGIA NGLDAKQWNP AADKMIKKKF DIERLSEKTE NKKYLLEEFG
MELEEATPLV GSVINAERFQ GSELLMESID GLMELDIQLV VSVSGDKELI RRLQEKAKAY
PEKLAVYSEF SDAIFHQIMA SSDLLLIPAE VESCGMMQLF AIAYGSVPVV YTAGGNIETI
EEIAGDKNGS AFVFHEYSVE SLLATFEDAL HTYADGERWE RIVTGNMVRD LTWKNSAAKY
NELYQGVRGG E
